node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
B0491.7 | mob-3 | B0491.7.1 | T12B3.4a.1 | TP_methylase domain-containing protein. | Mps One Binder (Mats/MOB1) homolog. | 0.430 |
gck-1 | mob-2 | T19A5.2b.1 | F09A5.4c.2 | Germinal center kinase 1; Serine/threonine-protein kinase which is required for normal oogenesis and suppression of germline cell apoptosis. Inhibits phosphorylation and thus probably activation of mpk-1 during pachytene stage. Involved in excretory canal elongation during postembryonic development, probably acting downstream of ccm-3 ; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. | Mps One Binder (Mats/MOB1) homolog. | 0.810 |
gck-1 | mob-3 | T19A5.2b.1 | T12B3.4a.1 | Germinal center kinase 1; Serine/threonine-protein kinase which is required for normal oogenesis and suppression of germline cell apoptosis. Inhibits phosphorylation and thus probably activation of mpk-1 during pachytene stage. Involved in excretory canal elongation during postembryonic development, probably acting downstream of ccm-3 ; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. | Mps One Binder (Mats/MOB1) homolog. | 0.781 |
gck-1 | mob-4 | T19A5.2b.1 | C30A5.3.1 | Germinal center kinase 1; Serine/threonine-protein kinase which is required for normal oogenesis and suppression of germline cell apoptosis. Inhibits phosphorylation and thus probably activation of mpk-1 during pachytene stage. Involved in excretory canal elongation during postembryonic development, probably acting downstream of ccm-3 ; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. | MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family. | 0.885 |
gck-1 | sax-1 | T19A5.2b.1 | R11G1.4a.1 | Germinal center kinase 1; Serine/threonine-protein kinase which is required for normal oogenesis and suppression of germline cell apoptosis. Inhibits phosphorylation and thus probably activation of mpk-1 during pachytene stage. Involved in excretory canal elongation during postembryonic development, probably acting downstream of ccm-3 ; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. | Serine/threonine-protein kinase sax-1; Acts with sax-2 to restrict the growth of both primary and secondary neurites. Regulates mechanosensory tiling by controlling the termination point of sensory dendrites; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | 0.703 |
gck-1 | tbck-1 | T19A5.2b.1 | C33F10.2.1 | Germinal center kinase 1; Serine/threonine-protein kinase which is required for normal oogenesis and suppression of germline cell apoptosis. Inhibits phosphorylation and thus probably activation of mpk-1 during pachytene stage. Involved in excretory canal elongation during postembryonic development, probably acting downstream of ccm-3 ; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. | TBC Kinase homolog. | 0.699 |
mob-2 | gck-1 | F09A5.4c.2 | T19A5.2b.1 | Mps One Binder (Mats/MOB1) homolog. | Germinal center kinase 1; Serine/threonine-protein kinase which is required for normal oogenesis and suppression of germline cell apoptosis. Inhibits phosphorylation and thus probably activation of mpk-1 during pachytene stage. Involved in excretory canal elongation during postembryonic development, probably acting downstream of ccm-3 ; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. | 0.810 |
mob-2 | mob-3 | F09A5.4c.2 | T12B3.4a.1 | Mps One Binder (Mats/MOB1) homolog. | Mps One Binder (Mats/MOB1) homolog. | 0.444 |
mob-2 | sax-1 | F09A5.4c.2 | R11G1.4a.1 | Mps One Binder (Mats/MOB1) homolog. | Serine/threonine-protein kinase sax-1; Acts with sax-2 to restrict the growth of both primary and secondary neurites. Regulates mechanosensory tiling by controlling the termination point of sensory dendrites; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | 0.983 |
mob-2 | tbck-1 | F09A5.4c.2 | C33F10.2.1 | Mps One Binder (Mats/MOB1) homolog. | TBC Kinase homolog. | 0.913 |
mob-2 | wts-1 | F09A5.4c.2 | T20F10.1.1 | Mps One Binder (Mats/MOB1) homolog. | Serine/threonine-protein kinase WARTS homolog; Phosphorylates yap-1 which may negatively regulate yap-1 nuclear localization. Plays an essential role in larval development. Regulates growth, the formation of gut granules, lifespan and cell and body sizes probably in synergy with the TGF-beta sma/mab pathway. Does not appear to regulate apoptosis and proliferation. In addition, may synergize with the TGF-beta daf-7 dauer pathway to regulate entry into the dauer stage. Maintains the cellular integrity of intestinal cells by regulating the localization of apical actin and junctional proteins. | 0.943 |
mob-3 | B0491.7 | T12B3.4a.1 | B0491.7.1 | Mps One Binder (Mats/MOB1) homolog. | TP_methylase domain-containing protein. | 0.430 |
mob-3 | gck-1 | T12B3.4a.1 | T19A5.2b.1 | Mps One Binder (Mats/MOB1) homolog. | Germinal center kinase 1; Serine/threonine-protein kinase which is required for normal oogenesis and suppression of germline cell apoptosis. Inhibits phosphorylation and thus probably activation of mpk-1 during pachytene stage. Involved in excretory canal elongation during postembryonic development, probably acting downstream of ccm-3 ; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. | 0.781 |
mob-3 | mob-2 | T12B3.4a.1 | F09A5.4c.2 | Mps One Binder (Mats/MOB1) homolog. | Mps One Binder (Mats/MOB1) homolog. | 0.444 |
mob-3 | mob-4 | T12B3.4a.1 | C30A5.3.1 | Mps One Binder (Mats/MOB1) homolog. | MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family. | 0.469 |
mob-3 | sax-1 | T12B3.4a.1 | R11G1.4a.1 | Mps One Binder (Mats/MOB1) homolog. | Serine/threonine-protein kinase sax-1; Acts with sax-2 to restrict the growth of both primary and secondary neurites. Regulates mechanosensory tiling by controlling the termination point of sensory dendrites; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | 0.823 |
mob-3 | tbck-1 | T12B3.4a.1 | C33F10.2.1 | Mps One Binder (Mats/MOB1) homolog. | TBC Kinase homolog. | 0.916 |
mob-3 | wts-1 | T12B3.4a.1 | T20F10.1.1 | Mps One Binder (Mats/MOB1) homolog. | Serine/threonine-protein kinase WARTS homolog; Phosphorylates yap-1 which may negatively regulate yap-1 nuclear localization. Plays an essential role in larval development. Regulates growth, the formation of gut granules, lifespan and cell and body sizes probably in synergy with the TGF-beta sma/mab pathway. Does not appear to regulate apoptosis and proliferation. In addition, may synergize with the TGF-beta daf-7 dauer pathway to regulate entry into the dauer stage. Maintains the cellular integrity of intestinal cells by regulating the localization of apical actin and junctional proteins. | 0.818 |
mob-4 | gck-1 | C30A5.3.1 | T19A5.2b.1 | MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family. | Germinal center kinase 1; Serine/threonine-protein kinase which is required for normal oogenesis and suppression of germline cell apoptosis. Inhibits phosphorylation and thus probably activation of mpk-1 during pachytene stage. Involved in excretory canal elongation during postembryonic development, probably acting downstream of ccm-3 ; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. | 0.885 |
mob-4 | mob-3 | C30A5.3.1 | T12B3.4a.1 | MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family. | Mps One Binder (Mats/MOB1) homolog. | 0.469 |