STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
glh-4ATP-dependent RNA helicase glh-4; Probable ATP-binding RNA helicase. May act redundantly with the P-granule component glh-1 to regulate the formation of the granular structure of P-granules in embryos. May protect somatic cells from excessive apoptosis during normal development. (1156 aa)    
Predicted Functional Partners:
pgl-3
Guanyl-specific ribonuclease pgl-3; Guanyl-specific endoribonuclease which cleaves the phosphodiester bond in single-stranded RNA between the 3'-guanylic residue and the 5'-OH residue of adjacent nucleotide, resulting in the formation of a corresponding 2',3'-cyclic phosphate intermediate. P-granule component involved in germline development. Together with the P-granule component pgl-1, is involved in the formation of P-granules. Together with pgl- 1, probably recruits other granule components such as pos-1, mex-3 and glh-1, and RNA to P-granules. In vitro, binds mRNA; this interaction [...]
  
 
 0.961
pgl-1
Guanyl-specific ribonuclease pgl-1; Guanyl-specific endoribonuclease which cleaves the phosphodiester bond in single-stranded RNA between the 3'-guanylic residue and the 5'-OH residue of adjacent nucleotide, resulting in the formation of a corresponding 2',3'-cyclic phosphate intermediate. Together with the P-granule component pgl-3, is involved in the formation of P-granules. Together with pgl-3, probably recruits other granule components such as pos-1, mex-3 and glh-1 to P-granules. In addition, may act redundantly with pgl-3 to protect germ cells from excessive germline apoptosis du [...]
  
 
 0.953
deps-1
Uncharacterized protein.
   
 
 0.843
meg-3
Uncharacterized protein.
   
 
 0.787
glh-1
ATP-dependent RNA helicase glh-1; Probable ATP-binding RNA helicase. May act redundantly with the P-granule component glh-4 to regulate the formation of the granular structure of P-granules in embryos. May play a role in transgenerational epigenetic inheritance. May protect somatic cells from excessive apoptosis during normal development. Belongs to the DEAD box helicase family. DDX4/VASA subfamily.
  
  
0.754
prg-1
Piwi-like protein; Belongs to the argonaute family.
   
 
 0.745
wago-1
Argonaute protein wago-1; Argonaute protein which is involved in the endogenous small interfering RNA (endo-siRNA) pathway. Interacts with secondary 22G- RNAs, which are RNA-dependent RNA polymerase-derived endo-siRNAs, typically 22 nucleotides in length with a 5'guanosine residue. In the germline, functions in a genome surveillance system to silence transposons and aberrant transcripts.
   
 
 0.714
meg-4
Uncharacterized protein.
   
  
 0.711
glh-2
ATP-dependent RNA helicase glh-2; Probable ATP-binding RNA helicase.
  
  
0.695
eftu-2
Tr-type G domain-containing protein.
   
 
 0.692
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.