STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pis-1PIS (Pax-2, IA-1/6, Smad-2 interacting protein) homolog. (1076 aa)    
Predicted Functional Partners:
utx-1
UTX (Ubiquitously transcribed TPR on X) homolog.
   
 0.996
rbbp-5
Retinoblastoma-binding protein homolog 5; Required for di- and trimethylation at 'Lys-4' of histone H3.
   
 0.992
set-16
Histone-lysine N-methyltransferase.
   
 0.987
ash-2
Set1/Ash2 histone methyltransferase complex subunit ash-2; Component of the set-2/ash-2 histone methyltransferase (HMT) complex (Probable). Required for the di- and trimethylation at 'Lys-4' of histone H3, a mark associated with epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Functions as transcriptional regulator. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturat [...]
   
 0.986
wdr-5.1
WD repeat-containing protein wdr-5.1; Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. Required for di- and trimethylation, particularly for the trimethylation at 'Lys-4' of histone H3. Not required for demethylation of histone H3 'Lys-27'. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, germline establishment, maintenance and function. Implicated in the epigenetic inheritance of lifespan over several generations. Acts in the germline to limit the longevity of the soma, pr [...]
   
 0.979
mus-101
Uncharacterized protein.
   
 
 0.964
hsr-9
Protein hsr-9; May have a role in DNA double-strand break repair following gamma-irradiation.
   
 
 0.963
atm-1
Serine/threonine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling in the presence of DNA double strand breaks (DSBs) and other forms of DNA damage induced by ionizing radiation and other genotoxic stresses such as UV. Plays a role in maintaining genome stability. Belongs to the PI3/PI4-kinase family. ATM subfamily.
   
 
 0.943
wdr-5.3
WD repeat-containing protein wdr-5.3; Not required for methylation of histone H3 'Lys-4'. Belongs to the WD repeat WDR5/wds family.
   
 0.935
smc-6
Structural maintenance of chromosomes protein 6 homolog smc-6; Core component of the smc-5/smc-6 complex. Involved in DNA double-strand break repair by promoting sister- chromatid homologous recombination during meiosis. Also plays a role in the DNA damage repair of ultraviolet (UV) radiation-induced DNA lesions. Promotes efficient DNA replication.
   
 
 0.921
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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