STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
T15B12.1Calponin-homology (CH) domain-containing protein. (432 aa)    
Predicted Functional Partners:
alp-1
ALP/Enigma encoding.
   
 
 0.626
mlc-4
Myosin regulatory light chain; Regulates myosin II activity and organization during embryo elongation. May be involved in the organization of mlc-5 into bundles. Required maternally for cytokinesis during meiosis and mitosis in the early embryo and for the establishment of embryonic anterior-posterior polarity.
   
 0.617
ckk-1
Calcium/calmodulin-dependent protein kinase kinase; Calcium/calmodulin-dependent protein kinase which phosphorylates cmk-1. Component of a calcium-triggered signaling cascade involved in CRE-mediated transcriptional activation, probably through cmk-1-mediated crh-1/CREB phosphorylation.
   
  
 0.592
ehbp-1
EH (Eps-15-homology) domain Binding Protein family.
   
 
0.591
ZK1321.4
PDZ domain-containing protein.
   
 
 0.565
exc-6
Excretory canal abnormal protein 6; Constitutively active protein required for microtubule and F- actin growth, structural maintenance and organization during excretory cell tubulogenesis.
   
 
  0.557
unc-43
Calcium/calmodulin-dependent protein kinase type II; Acts in the signaling of a variety of pathways and processes. Phosphorylates 'Ser-319' of daf-16 in response to stress signals, such as heat, starvation and oxidation, which plays a role in prolonging lifespan. Required for viability under chronic osmotic stress in which it acts downstream of osr-1. Has roles in locomotion, oocyte maturation, brood size, egg laying, defecation, meiotic maturation and neuronal cell fate specification. Required for the regulation of synaptic density and neuromuscular junction morphology. Regulates the [...]
   
   0.541
mig-10
Abnormal cell migration protein 10; Required cell non-autonomously for proper development of the excretory canals and for the long-range anterior-posterior migrations of embryonic neurons CAN, ALM and HSN. Plays a role, probably downstream of ced-10/rac1, in orientating axonal growth of HSN and AVM neurons in response to guidance cues such as slt- 1. May regulate growth cone polarization by promoting asymmetric F-actin assembly. May be involved in signal transduction during cell migration. Belongs to the MRL family.
     
  0.540
cerk-1
Ceramide kinase 1; Catalyzes the phosphorylation of ceramide to form ceramide 1- phosphate.
      
 0.467
cpn-4
Calponin-homology (CH) domain-containing protein.
   
  
 0.446
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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