STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nhr-77Nuclear hormone receptor family member nhr-77; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (362 aa)    
Predicted Functional Partners:
gmeb-1
SAND domain-containing protein.
    
 
 0.806
nhr-276
Nuclear Hormone Receptor family.
      
 0.699
Y87G2A.2
Uncharacterized protein.
      
 0.699
W03F9.2
C2H2-type domain-containing protein.
      
 0.695
catp-8
Probable manganese-transporting ATPase catp-8; Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis.
      
 0.660
T27F6.6
Putative neutral sphingomyelinase.
      
 0.619
fos-1
Transcription factor fos-1; Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGA[CG]TCA-3'. [Isoform b]: Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1 ; Belongs to the bZIP family. Fos subfamily.
    
 
 0.609
ets-9
ETS domain-containing protein.
    
 
 0.552
pqm-1
C2H2-type domain-containing protein.
    
 
 0.544
ceh-5
Homeobox protein ceh-5.
      
 0.533
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.