STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ver-1Protein ver-1; Involved in amphid glia remodeling during entry into dauer stage by promoting the fusion of sheath amphid cells which encloses AWC neuron sensory endings. May be involved, downstream of pvf-1, in the positioning of ray 1, the most anterior ray sensillum in the male tail. (1083 aa)    
Predicted Functional Partners:
let-756
Protein let-756; Required for larval development. Probably by binding receptor egl-15, regulates negatively membrane protrusion from body wall muscles during larval development.
   
 0.948
sem-5
Sex muscle abnormal protein 5; Adapter protein which modulates signaling mediated by several receptor tyrosine kinases such as egl-15 and let-23 probably acting upstream of let-60/ras. Negatively regulates vulva induction probably downstream of let-23. Involved in sex myoblast migration. Negatively regulates fluid homeostasis probably downstream of egl-15. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of egl- 15. Involved in cytoskeleton dynamics and is recruited by mig-13 to the [...]
   
 0.932
pvf-1
PDGF_2 domain-containing protein.
    
 0.856
ztf-16
Zinc finger protein ztf-16; Positively regulates the expression of ver-1 in the amphid sheath glia of amphid sensory neurons. Together with ehn-3, plays a role in somatic gonad development and is required for proper gonadal primordium assembly and somatic gonad precursor cell morphology ; Belongs to the Ikaros C2H2-type zinc-finger protein family.
      
 0.809
sqst-5
Protein ver-2; May be involved, downstream of pvf-1, in the positioning of ray 1, the most anterior ray sensillum in the male tail.
      
 0.807
ttx-1
Homeobox domain-containing protein.
      
 0.807
aff-1
Cell fusion protein aff-1; Required for cell fusion events during development including the fusion of anchor cells (AC), vulval A and vulval D rings, and late epidermal seam cells. Required for amphid sheath cell fusion induced by entry into dauer stage.
      
 0.758
F47D2.11
Uncharacterized protein.
      
 0.758
baz-2
Bromodomain Adjacent to Zinc finger domain, 2A/2B, homolog.
    
 
 0.708
F58F9.6
Uncharacterized protein.
   
  
 0.699
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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