STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gck-1Germinal center kinase 1; Serine/threonine-protein kinase which is required for normal oogenesis and suppression of germline cell apoptosis. Inhibits phosphorylation and thus probably activation of mpk-1 during pachytene stage. Involved in excretory canal elongation during postembryonic development, probably acting downstream of ccm-3 ; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (803 aa)    
Predicted Functional Partners:
ccm-3
Programmed cell death protein 10 homolog; Involved in excretory canal elongation during postembryonic development. Plays a role in promoting Golgi stability, ER integrity and vesicle transport probably by regulating the activation of Rho GTPase cdc-42. Involved in fertility.
    
 
 0.990
cash-1
WD_REPEATS_REGION domain-containing protein.
   
 
 0.977
farl-11
DUF3402 domain-containing protein.
   
 
 0.959
C49H3.6
CortBP2 domain-containing protein.
    
 
 0.929
mob-4
MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family.
    
 
 0.885
let-92
Serine/threonine-protein phosphatase 2A catalytic subunit; Protein phosphatase which plays an essential role in early embryonic cell division. Probably together with constant regulatory subunit paa-1 and regulatory subunit sur-6, positively regulates centriole duplication by preventing the degradation of sas-5 and kinase zyg-1. In addition, plays a role in the recruitment of sas- 6 and maybe sas-5 to centrioles and may dephosphorylate sas-5 and zyg-1 negative regulator szy-20. During vulva development, may play a role with regulatory subunits paa-1 and sur-6 in the induction of vulva c [...]
   
 
 0.872
mob-2
Mps One Binder (Mats/MOB1) homolog.
   
 
 0.810
mob-1
Mps One Binder (Mats/MOB1) homolog.
    
 
 0.807
mob-3
Mps One Binder (Mats/MOB1) homolog.
   
  
 0.781
mop-25.2
MO25-like protein 2; Regulates asymmetric cell division in Q.p neuroblast lineage. Plays a role in cell shedding during embryogenesis.
   
 
 0.774
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.