node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
H28G03.1 | nhr-69 | H28G03.1a.1 | T23H4.2.1 | Uncharacterized protein. | Nuclear hormone receptor family member nhr-69; Orphan nuclear receptor. | 0.538 |
W08E12.7 | nhr-69 | W08E12.7.1 | T23H4.2.1 | Peptidase_M24 domain-containing protein. | Nuclear hormone receptor family member nhr-69; Orphan nuclear receptor. | 0.470 |
daf-14 | daf-16 | F01G10.8b.1 | R13H8.1h.1 | MH2 domain-containing protein. | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | 0.437 |
daf-14 | daf-3 | F01G10.8b.1 | F25E2.5d.1 | MH2 domain-containing protein. | Dwarfin sma. | 0.789 |
daf-14 | daf-8 | F01G10.8b.1 | R05D11.1.1 | MH2 domain-containing protein. | Dwarfin sma. | 0.868 |
daf-14 | nhr-69 | F01G10.8b.1 | T23H4.2.1 | MH2 domain-containing protein. | Nuclear hormone receptor family member nhr-69; Orphan nuclear receptor. | 0.503 |
daf-14 | pax-2 | F01G10.8b.1 | K06B9.5a.1 | MH2 domain-containing protein. | Paired domain-containing protein. | 0.566 |
daf-16 | daf-14 | R13H8.1h.1 | F01G10.8b.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | MH2 domain-containing protein. | 0.437 |
daf-16 | daf-3 | R13H8.1h.1 | F25E2.5d.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Dwarfin sma. | 0.932 |
daf-16 | daf-8 | R13H8.1h.1 | R05D11.1.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Dwarfin sma. | 0.813 |
daf-16 | gei-8 | R13H8.1h.1 | C14B9.6a.3 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Plays a role in development and neuronal function. May play a role in muscle-specific oxidative mitochondrial metabolism. | 0.506 |
daf-16 | mdt-15 | R13H8.1h.1 | R12B2.5a.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] | 0.726 |
daf-16 | nhr-69 | R13H8.1h.1 | T23H4.2.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Nuclear hormone receptor family member nhr-69; Orphan nuclear receptor. | 0.465 |
daf-3 | daf-14 | F25E2.5d.1 | F01G10.8b.1 | Dwarfin sma. | MH2 domain-containing protein. | 0.789 |
daf-3 | daf-16 | F25E2.5d.1 | R13H8.1h.1 | Dwarfin sma. | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | 0.932 |
daf-3 | daf-8 | F25E2.5d.1 | R05D11.1.1 | Dwarfin sma. | Dwarfin sma. | 0.947 |
daf-3 | nhr-69 | F25E2.5d.1 | T23H4.2.1 | Dwarfin sma. | Nuclear hormone receptor family member nhr-69; Orphan nuclear receptor. | 0.497 |
daf-3 | pax-2 | F25E2.5d.1 | K06B9.5a.1 | Dwarfin sma. | Paired domain-containing protein. | 0.452 |
daf-8 | daf-14 | R05D11.1.1 | F01G10.8b.1 | Dwarfin sma. | MH2 domain-containing protein. | 0.868 |
daf-8 | daf-16 | R05D11.1.1 | R13H8.1h.1 | Dwarfin sma. | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | 0.813 |