STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
shc-2SH2 domain-containing protein. (638 aa)    
Predicted Functional Partners:
pes-7
Patterned Expression Site.
      
 0.697
doxa-1
Dual oxidase maturation factor 1; Plays a role in cuticle biogenesis. In complex with tsp-15 and the dual oxidase bli-3, promotes the generation of reactive oxygen species (ROS) and tyrosine cross-linking of collagen, thus stabilizing cuticular extracellular matrix.
      
 0.661
memo-1
Protein memo-1 homolog; Plays a role in the oxidative stress response and the maintenance of longevity by regulating the interaction between GTPase rho-1 and oxidase bli-3. In turn, this serves to modulate bli-3 activity and the control of reactive oxygen species production. May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton (By similarity); Belongs to the MEMO1 family.
   
  
 0.661
shc-1
SHC-transforming protein homolog 1; Scaffold protein which plays an important role in the activation of the JNK pathway composed of mlk-1, mek-1 and kgb-1; by bringing together mek-1 and mlk-1, promotes mlk-1-mediated phosphorylation and activation of mek-1 which in turn phosphorylates kgb-1. In addition, negatively modulates the activation of the insulin/IGF-1-like signaling (IIS) probably by inhibiting the insulin receptor daf-2. Positively regulates the activity of the transcription factor daf-16/FOXO by both inhibiting IIS and activating the JNK pathway. Involved in the response to [...]
      
 0.614
cup-4
Acetylcholine receptor-like protein cup-4; Thought to regulate endocytosis in coelomocytes through modulation of phospholipase C activity. Possible acetylcholine receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
      
 0.499
duox-2
DUal OXidase.
      
 0.467
btb-14
BTB/POZ domain-containing protein Y57A10B.3.
      
 0.422
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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