node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
btb-14 | memo-1 | Y57A10B.3.1 | C37C3.8c.1 | BTB/POZ domain-containing protein Y57A10B.3. | Protein memo-1 homolog; Plays a role in the oxidative stress response and the maintenance of longevity by regulating the interaction between GTPase rho-1 and oxidase bli-3. In turn, this serves to modulate bli-3 activity and the control of reactive oxygen species production. May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton (By similarity); Belongs to the MEMO1 family. | 0.662 |
btb-14 | shc-2 | Y57A10B.3.1 | T27F7.2a.1 | BTB/POZ domain-containing protein Y57A10B.3. | SH2 domain-containing protein. | 0.422 |
cup-4 | shc-2 | C02C2.3.1 | T27F7.2a.1 | Acetylcholine receptor-like protein cup-4; Thought to regulate endocytosis in coelomocytes through modulation of phospholipase C activity. Possible acetylcholine receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. | SH2 domain-containing protein. | 0.499 |
doxa-1 | duox-2 | C06E1.3.1 | F53G12.3.1 | Dual oxidase maturation factor 1; Plays a role in cuticle biogenesis. In complex with tsp-15 and the dual oxidase bli-3, promotes the generation of reactive oxygen species (ROS) and tyrosine cross-linking of collagen, thus stabilizing cuticular extracellular matrix. | DUal OXidase. | 0.930 |
doxa-1 | memo-1 | C06E1.3.1 | C37C3.8c.1 | Dual oxidase maturation factor 1; Plays a role in cuticle biogenesis. In complex with tsp-15 and the dual oxidase bli-3, promotes the generation of reactive oxygen species (ROS) and tyrosine cross-linking of collagen, thus stabilizing cuticular extracellular matrix. | Protein memo-1 homolog; Plays a role in the oxidative stress response and the maintenance of longevity by regulating the interaction between GTPase rho-1 and oxidase bli-3. In turn, this serves to modulate bli-3 activity and the control of reactive oxygen species production. May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton (By similarity); Belongs to the MEMO1 family. | 0.667 |
doxa-1 | pes-7 | C06E1.3.1 | F09C3.1.1 | Dual oxidase maturation factor 1; Plays a role in cuticle biogenesis. In complex with tsp-15 and the dual oxidase bli-3, promotes the generation of reactive oxygen species (ROS) and tyrosine cross-linking of collagen, thus stabilizing cuticular extracellular matrix. | Patterned Expression Site. | 0.491 |
doxa-1 | shc-2 | C06E1.3.1 | T27F7.2a.1 | Dual oxidase maturation factor 1; Plays a role in cuticle biogenesis. In complex with tsp-15 and the dual oxidase bli-3, promotes the generation of reactive oxygen species (ROS) and tyrosine cross-linking of collagen, thus stabilizing cuticular extracellular matrix. | SH2 domain-containing protein. | 0.661 |
duox-2 | doxa-1 | F53G12.3.1 | C06E1.3.1 | DUal OXidase. | Dual oxidase maturation factor 1; Plays a role in cuticle biogenesis. In complex with tsp-15 and the dual oxidase bli-3, promotes the generation of reactive oxygen species (ROS) and tyrosine cross-linking of collagen, thus stabilizing cuticular extracellular matrix. | 0.930 |
duox-2 | shc-2 | F53G12.3.1 | T27F7.2a.1 | DUal OXidase. | SH2 domain-containing protein. | 0.467 |
memo-1 | btb-14 | C37C3.8c.1 | Y57A10B.3.1 | Protein memo-1 homolog; Plays a role in the oxidative stress response and the maintenance of longevity by regulating the interaction between GTPase rho-1 and oxidase bli-3. In turn, this serves to modulate bli-3 activity and the control of reactive oxygen species production. May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton (By similarity); Belongs to the MEMO1 family. | BTB/POZ domain-containing protein Y57A10B.3. | 0.662 |
memo-1 | doxa-1 | C37C3.8c.1 | C06E1.3.1 | Protein memo-1 homolog; Plays a role in the oxidative stress response and the maintenance of longevity by regulating the interaction between GTPase rho-1 and oxidase bli-3. In turn, this serves to modulate bli-3 activity and the control of reactive oxygen species production. May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton (By similarity); Belongs to the MEMO1 family. | Dual oxidase maturation factor 1; Plays a role in cuticle biogenesis. In complex with tsp-15 and the dual oxidase bli-3, promotes the generation of reactive oxygen species (ROS) and tyrosine cross-linking of collagen, thus stabilizing cuticular extracellular matrix. | 0.667 |
memo-1 | pes-7 | C37C3.8c.1 | F09C3.1.1 | Protein memo-1 homolog; Plays a role in the oxidative stress response and the maintenance of longevity by regulating the interaction between GTPase rho-1 and oxidase bli-3. In turn, this serves to modulate bli-3 activity and the control of reactive oxygen species production. May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton (By similarity); Belongs to the MEMO1 family. | Patterned Expression Site. | 0.461 |
memo-1 | shc-2 | C37C3.8c.1 | T27F7.2a.1 | Protein memo-1 homolog; Plays a role in the oxidative stress response and the maintenance of longevity by regulating the interaction between GTPase rho-1 and oxidase bli-3. In turn, this serves to modulate bli-3 activity and the control of reactive oxygen species production. May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton (By similarity); Belongs to the MEMO1 family. | SH2 domain-containing protein. | 0.661 |
pes-7 | doxa-1 | F09C3.1.1 | C06E1.3.1 | Patterned Expression Site. | Dual oxidase maturation factor 1; Plays a role in cuticle biogenesis. In complex with tsp-15 and the dual oxidase bli-3, promotes the generation of reactive oxygen species (ROS) and tyrosine cross-linking of collagen, thus stabilizing cuticular extracellular matrix. | 0.491 |
pes-7 | memo-1 | F09C3.1.1 | C37C3.8c.1 | Patterned Expression Site. | Protein memo-1 homolog; Plays a role in the oxidative stress response and the maintenance of longevity by regulating the interaction between GTPase rho-1 and oxidase bli-3. In turn, this serves to modulate bli-3 activity and the control of reactive oxygen species production. May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton (By similarity); Belongs to the MEMO1 family. | 0.461 |
pes-7 | shc-1 | F09C3.1.1 | F54A5.3a.1 | Patterned Expression Site. | SHC-transforming protein homolog 1; Scaffold protein which plays an important role in the activation of the JNK pathway composed of mlk-1, mek-1 and kgb-1; by bringing together mek-1 and mlk-1, promotes mlk-1-mediated phosphorylation and activation of mek-1 which in turn phosphorylates kgb-1. In addition, negatively modulates the activation of the insulin/IGF-1-like signaling (IIS) probably by inhibiting the insulin receptor daf-2. Positively regulates the activity of the transcription factor daf-16/FOXO by both inhibiting IIS and activating the JNK pathway. Involved in the response to [...] | 0.433 |
pes-7 | shc-2 | F09C3.1.1 | T27F7.2a.1 | Patterned Expression Site. | SH2 domain-containing protein. | 0.697 |
shc-1 | pes-7 | F54A5.3a.1 | F09C3.1.1 | SHC-transforming protein homolog 1; Scaffold protein which plays an important role in the activation of the JNK pathway composed of mlk-1, mek-1 and kgb-1; by bringing together mek-1 and mlk-1, promotes mlk-1-mediated phosphorylation and activation of mek-1 which in turn phosphorylates kgb-1. In addition, negatively modulates the activation of the insulin/IGF-1-like signaling (IIS) probably by inhibiting the insulin receptor daf-2. Positively regulates the activity of the transcription factor daf-16/FOXO by both inhibiting IIS and activating the JNK pathway. Involved in the response to [...] | Patterned Expression Site. | 0.433 |
shc-1 | shc-2 | F54A5.3a.1 | T27F7.2a.1 | SHC-transforming protein homolog 1; Scaffold protein which plays an important role in the activation of the JNK pathway composed of mlk-1, mek-1 and kgb-1; by bringing together mek-1 and mlk-1, promotes mlk-1-mediated phosphorylation and activation of mek-1 which in turn phosphorylates kgb-1. In addition, negatively modulates the activation of the insulin/IGF-1-like signaling (IIS) probably by inhibiting the insulin receptor daf-2. Positively regulates the activity of the transcription factor daf-16/FOXO by both inhibiting IIS and activating the JNK pathway. Involved in the response to [...] | SH2 domain-containing protein. | 0.614 |
shc-2 | btb-14 | T27F7.2a.1 | Y57A10B.3.1 | SH2 domain-containing protein. | BTB/POZ domain-containing protein Y57A10B.3. | 0.422 |