STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mnr-1MeNoRin (Dendritic branching protein). (530 aa)    
Predicted Functional Partners:
sax-7
Fibronectin type-III domain-containing protein.
    
 
 0.995
dma-1
LRRCT domain-containing protein.
   
 
 0.985
hpo-30
Uncharacterized protein.
      
 0.970
lect-2
Peptidase_M23 domain-containing protein.
      
 0.968
tiam-1
DH domain-containing protein.
   
  
 0.849
act-4
Actin-4; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
   
  
 0.816
H24G06.1
Uncharacterized protein.
   
  
 0.777
kpc-1
Furin-like protease kpc-1; Furin-like protease which cleaves proproteins at the RX(K/R)R consensus motif. During neuronal development, regulates the formation and extension of dendrite branches and cellular positioning of various type of neurons. Promotes the formation, extension and self-avoidance of dendritic branches of PVD and FLP mechanosensory neurons. In PVD neurons, regulates plasma membrane levels of branching receptor dma-1 by targeting it to late endosomes and thus promotes normal dendrite branching and dendrite self-avoidance. Also controls dendrite extension in AIY and D-t [...]
   
  
 0.764
clr-1
Receptor-type tyrosine-protein phosphatase; Possesses an intrinsic protein tyrosine phosphatase (PTPase) activity. Regulates egl-15 activity which is required for hypodermis-mediated fluid homeostasis and protein degradation in muscle. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles. Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine. Regulates synaptic levels of nAchR subunit lev-1 in the nerve cord. Promotes the outgrowth of the quaternary dendritic branches of [...]
      
 0.660
bicd-1
Protein bicaudal D homolog; Part of a complex with dlc-1 and egal-1, which is recruited to the nuclear envelope by unc-83, where in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells (Probable). Required for the formation of dendritic branches of PVD sensory neurons ; Belongs to the BicD family.
   
  
 0.623
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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