STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cisd-1ZnF_CDGSH domain-containing protein. (134 aa)    
Predicted Functional Partners:
cisd-3.2
CDGSH Iron Sulfur Domain protein homolog.
   
  
 0.920
ddb-1
DNA damage-binding protein 1; Plays a role in DNA repair. May be a component of an E3 ubiquitin-protein ligase which promotes histone ubiquitination in response to UV irradiation. Histone ubiquitination may be important for subsequent DNA repair (By similarity). Promotes the degradation of the replication licensing factor cdt-1 during S-phase, thereby preventing rereplication of DNA during a single round of cell division.
    
 
 0.908
cisd-3.1
CDGSH Iron Sulfur Domain protein homolog.
   
  
 0.899
B0205.6
Aminotran_5 domain-containing protein.
      
 0.693
aco-1
Probable cytoplasmic aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
   
 
 0.560
lem-2
LEM protein 2; Essential protein involved in chromosome segregation and cell division, probably via its interaction with lmn-1, the main component of nuclear lamina. Has some overlapping function with emr-1. May play a role in radiation-induced DNA damage repair response.
    
 
 0.548
rbm-39
RNA Binding Motif protein homolog.
    
 
 0.548
nduf-5
NADH Ubiquinone oxidoreductase Fe-S protein.
   
 
 0.535
tomm-70
Mitochondrial import receptor subunit tomm-70; Receptor that accelerates the import of all mitochondrial precursor proteins; Belongs to the Tom70 family.
      
 0.485
Y105E8A.11
Uncharacterized protein; Belongs to the BolA/IbaG family.
   
  
 0.478
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.