node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C50F4.16 | ndx-1 | C50F4.16.1 | T26E3.2.1 | Nudix hydrolase domain-containing protein. | Putative nudix hydrolase 1; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family. | 0.668 |
C50F4.16 | ndx-2 | C50F4.16.1 | W02G9.1.1 | Nudix hydrolase domain-containing protein. | Putative nudix hydrolase 2; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family. | 0.669 |
C50F4.16 | ndx-4 | C50F4.16.1 | Y37H9A.6.1 | Nudix hydrolase domain-containing protein. | Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. | 0.545 |
C50F4.16 | ndx-6 | C50F4.16.1 | EEED8.8.1 | Nudix hydrolase domain-containing protein. | Putative nudix hydrolase 6; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family. | 0.646 |
chk-2 | clk-2 | Y60A3A.12.1 | C07H6.6.1 | Serine/threonine-protein kinase chk-2; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Phosphorylates and inhibits cdc25 phosphatase, preventing entry into mitosis. Required for nuclear reorganization and homologous chromosome pairing during meiotic prophase. | Telomere length regulation protein clk-2; DNA damage checkpoint protein required for DNA damage-induced cell cycle arrest and apoptosis, thereby playing a role in genome stability. Regulator of telomere length. Belongs to the TEL2 family. | 0.450 |
chk-2 | ndx-2 | Y60A3A.12.1 | W02G9.1.1 | Serine/threonine-protein kinase chk-2; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Phosphorylates and inhibits cdc25 phosphatase, preventing entry into mitosis. Required for nuclear reorganization and homologous chromosome pairing during meiotic prophase. | Putative nudix hydrolase 2; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family. | 0.660 |
clk-2 | chk-2 | C07H6.6.1 | Y60A3A.12.1 | Telomere length regulation protein clk-2; DNA damage checkpoint protein required for DNA damage-induced cell cycle arrest and apoptosis, thereby playing a role in genome stability. Regulator of telomere length. Belongs to the TEL2 family. | Serine/threonine-protein kinase chk-2; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Phosphorylates and inhibits cdc25 phosphatase, preventing entry into mitosis. Required for nuclear reorganization and homologous chromosome pairing during meiotic prophase. | 0.450 |
clk-2 | dut-1 | C07H6.6.1 | K07A1.2.3 | Telomere length regulation protein clk-2; DNA damage checkpoint protein required for DNA damage-induced cell cycle arrest and apoptosis, thereby playing a role in genome stability. Regulator of telomere length. Belongs to the TEL2 family. | Deoxyuridinetriphosphatase. | 0.575 |
clk-2 | exo-3 | C07H6.6.1 | R09B3.1a.1 | Telomere length regulation protein clk-2; DNA damage checkpoint protein required for DNA damage-induced cell cycle arrest and apoptosis, thereby playing a role in genome stability. Regulator of telomere length. Belongs to the TEL2 family. | DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family. | 0.404 |
clk-2 | ndx-1 | C07H6.6.1 | T26E3.2.1 | Telomere length regulation protein clk-2; DNA damage checkpoint protein required for DNA damage-induced cell cycle arrest and apoptosis, thereby playing a role in genome stability. Regulator of telomere length. Belongs to the TEL2 family. | Putative nudix hydrolase 1; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family. | 0.662 |
clk-2 | ndx-2 | C07H6.6.1 | W02G9.1.1 | Telomere length regulation protein clk-2; DNA damage checkpoint protein required for DNA damage-induced cell cycle arrest and apoptosis, thereby playing a role in genome stability. Regulator of telomere length. Belongs to the TEL2 family. | Putative nudix hydrolase 2; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family. | 0.808 |
clk-2 | ndx-4 | C07H6.6.1 | Y37H9A.6.1 | Telomere length regulation protein clk-2; DNA damage checkpoint protein required for DNA damage-induced cell cycle arrest and apoptosis, thereby playing a role in genome stability. Regulator of telomere length. Belongs to the TEL2 family. | Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. | 0.469 |
dut-1 | clk-2 | K07A1.2.3 | C07H6.6.1 | Deoxyuridinetriphosphatase. | Telomere length regulation protein clk-2; DNA damage checkpoint protein required for DNA damage-induced cell cycle arrest and apoptosis, thereby playing a role in genome stability. Regulator of telomere length. Belongs to the TEL2 family. | 0.575 |
dut-1 | exo-3 | K07A1.2.3 | R09B3.1a.1 | Deoxyuridinetriphosphatase. | DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family. | 0.929 |
dut-1 | ndx-1 | K07A1.2.3 | T26E3.2.1 | Deoxyuridinetriphosphatase. | Putative nudix hydrolase 1; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family. | 0.748 |
dut-1 | ndx-2 | K07A1.2.3 | W02G9.1.1 | Deoxyuridinetriphosphatase. | Putative nudix hydrolase 2; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family. | 0.835 |
dut-1 | ndx-4 | K07A1.2.3 | Y37H9A.6.1 | Deoxyuridinetriphosphatase. | Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. | 0.724 |
dut-1 | nth-1 | K07A1.2.3 | R10E4.5d.1 | Deoxyuridinetriphosphatase. | Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. | 0.835 |
dut-1 | ung-1 | K07A1.2.3 | Y56A3A.29a.1 | Deoxyuridinetriphosphatase. | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.966 |
exo-3 | clk-2 | R09B3.1a.1 | C07H6.6.1 | DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family. | Telomere length regulation protein clk-2; DNA damage checkpoint protein required for DNA damage-induced cell cycle arrest and apoptosis, thereby playing a role in genome stability. Regulator of telomere length. Belongs to the TEL2 family. | 0.404 |