node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
T27F6.6 | W02F12.2 | T27F6.6.1 | W02F12.2.1 | Putative neutral sphingomyelinase. | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid; Belongs to the alkaline ceramidase family. | 0.956 |
T27F6.6 | asah-1 | T27F6.6.1 | K11D2.2.1 | Putative neutral sphingomyelinase. | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH. | 0.917 |
T27F6.6 | asm-2 | T27F6.6.1 | ZK455.4.1 | Putative neutral sphingomyelinase. | Sphingomyelin phosphodiesterase 2; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family. | 0.933 |
T27F6.6 | asm-3 | T27F6.6.1 | W03G1.7a.1 | Putative neutral sphingomyelinase. | Putative sphingomyelin phosphodiesterase asm-3; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family. | 0.933 |
T27F6.6 | cgt-1 | T27F6.6.1 | T06C12.10.1 | Putative neutral sphingomyelinase. | Ceramide glucosyltransferase 1; Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. Belongs to the glycosyltransferase 2 family. | 0.927 |
T27F6.6 | cgt-2 | T27F6.6.1 | F20B4.6.1 | Putative neutral sphingomyelinase. | Ceramide glucosyltransferase 2; Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. Belongs to the glycosyltransferase 2 family. | 0.927 |
T27F6.6 | hyl-1 | T27F6.6.1 | C09G4.1b.1 | Putative neutral sphingomyelinase. | Ceramide synthase hyl-1; Catalyzes the acylation of sphingosine to form ceramides. Exhibits substrate preference for fatty acyl-coA chains containing 24 and 26 carbons. | 0.934 |
T27F6.6 | hyl-2 | T27F6.6.1 | K02G10.6.1 | Putative neutral sphingomyelinase. | Ceramide synthase hyl-2; Catalyzes the acylation of sphingosine to form ceramides. Exhibits substrate preference for fatty acyl-coA chains containing 20 and 22 carbons. Required for adaptation of the nematode to anoxia. Anoxia tolerance may require one or more of the ceramide species that are either specifically or preferentially synthesized by hyl-2, and seems to be effected by a pathway that is parallel to that involving daf-2. | 0.962 |
T27F6.6 | lagr-1 | T27F6.6.1 | Y6B3B.10.1 | Putative neutral sphingomyelinase. | Probable ceramide synthase lagr-1; Catalyzes the acylation of sphingosine to form ceramides. | 0.979 |
T27F6.6 | sms-1 | T27F6.6.1 | H21P03.3b.1 | Putative neutral sphingomyelinase. | Phosphatidylcholine:ceramide cholinephosphotransferase 1; Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. | 0.940 |
W02F12.2 | T27F6.6 | W02F12.2.1 | T27F6.6.1 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid; Belongs to the alkaline ceramidase family. | Putative neutral sphingomyelinase. | 0.956 |
W02F12.2 | asah-1 | W02F12.2.1 | K11D2.2.1 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid; Belongs to the alkaline ceramidase family. | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH. | 0.977 |
W02F12.2 | asm-2 | W02F12.2.1 | ZK455.4.1 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid; Belongs to the alkaline ceramidase family. | Sphingomyelin phosphodiesterase 2; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family. | 0.909 |
W02F12.2 | asm-3 | W02F12.2.1 | W03G1.7a.1 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid; Belongs to the alkaline ceramidase family. | Putative sphingomyelin phosphodiesterase asm-3; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family. | 0.929 |
W02F12.2 | cgt-1 | W02F12.2.1 | T06C12.10.1 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid; Belongs to the alkaline ceramidase family. | Ceramide glucosyltransferase 1; Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. Belongs to the glycosyltransferase 2 family. | 0.921 |
W02F12.2 | cgt-2 | W02F12.2.1 | F20B4.6.1 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid; Belongs to the alkaline ceramidase family. | Ceramide glucosyltransferase 2; Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. Belongs to the glycosyltransferase 2 family. | 0.968 |
W02F12.2 | hyl-1 | W02F12.2.1 | C09G4.1b.1 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid; Belongs to the alkaline ceramidase family. | Ceramide synthase hyl-1; Catalyzes the acylation of sphingosine to form ceramides. Exhibits substrate preference for fatty acyl-coA chains containing 24 and 26 carbons. | 0.942 |
W02F12.2 | hyl-2 | W02F12.2.1 | K02G10.6.1 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid; Belongs to the alkaline ceramidase family. | Ceramide synthase hyl-2; Catalyzes the acylation of sphingosine to form ceramides. Exhibits substrate preference for fatty acyl-coA chains containing 20 and 22 carbons. Required for adaptation of the nematode to anoxia. Anoxia tolerance may require one or more of the ceramide species that are either specifically or preferentially synthesized by hyl-2, and seems to be effected by a pathway that is parallel to that involving daf-2. | 0.955 |
W02F12.2 | lagr-1 | W02F12.2.1 | Y6B3B.10.1 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid; Belongs to the alkaline ceramidase family. | Probable ceramide synthase lagr-1; Catalyzes the acylation of sphingosine to form ceramides. | 0.944 |
W02F12.2 | sms-1 | W02F12.2.1 | H21P03.3b.1 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid; Belongs to the alkaline ceramidase family. | Phosphatidylcholine:ceramide cholinephosphotransferase 1; Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. | 0.978 |