STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ret-1Reticulon-like protein. (3303 aa)    
Predicted Functional Partners:
yop-1
Receptor expression-enhancing protein.
   
 
 0.908
lnp-1
Endoplasmic reticulum junction formation protein lunapark-1; Plays a role in tubular endoplasmic reticulum network formation and maintenance (By similarity). May be involved in central nervous system development. Has a presynaptic role in neurotransmission. Likely to operate in synaptogenesis by regulating vesicular transport or localization. Required for correct localization of rab-3 and snb-1; Belongs to the lunapark family.
    
 
 0.865
cat-4
GTP cyclohydrolase 1; Involved in serotonin and dopamine biosynthesis that affects movement, mating behavior, foraging behavior, and cell migration.
    
   0.851
T19C3.4
Uncharacterized protein T19C3.4.
   
 
 0.829
atln-1
GB1/RHD3-type G domain-containing protein.
   
 
 0.797
Y38F2AR.9
Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.
   
 
 0.790
larp-1
La-related protein 1; RNA-binding protein that promotes oogenesis by repressing fem-3 expression during germline development. Binds poly-U and poly-G stretches of RNA in vitro. Regulates target RNAs expression either by regulating their stability or translation.
   
 
 0.743
C07A12.7
GAT domain-containing protein.
   
  
 0.722
npp-25
Transmembrane protein 33 homolog.
   
 
 0.718
dnj-29
J domain-containing protein.
   
 
 0.710
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.