STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rom-4Rhomboid domain-containing protein. (1205 aa)    
Predicted Functional Partners:
pink-1
Serine/threonine-protein kinase pink-1, mitochondrial; Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins (By similarity). Plays a role in mitophagy.
   
 
 0.806
rom-5
Rhomboid domain-containing protein.
      
 0.796
pgam-5
Serine/threonine-protein phosphatase Pgam5, mitochondrial; Displays phosphatase activity for serine/threonine residues. Has apparently no phosphoglycerate mutase activity (By similarity). Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.
   
  
 0.752
ppgn-1
AAA domain-containing protein.
   
  
 0.727
Y19D10A.6
Metalloendopeptidase.
      
 0.664
fzo-1
Transmembrane GTPase fzo-1; Probable transmembrane GTPase (By similarity). Mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission (By similarity); Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily.
   
 
 0.654
pdr-1
E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.
   
 
 0.622
fis-1
Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.
    
 
 0.616
nas-2
Zinc metalloproteinase nas-2; Metalloprotease.
      
 0.610
nas-10
Zinc metalloproteinase nas-10; Metalloprotease.
      
 0.610
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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