STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sfa-1CCHC-type domain-containing protein. (699 aa)    
Predicted Functional Partners:
uaf-1
Splicing factor U2AF 65 kDa subunit; Necessary for the splicing of pre-mRNA. Binds to the polypyrimidine tract of introns early during spliceosome assembly (By similarity).
   
 
 0.999
repo-1
Matrin-type domain-containing protein.
   
 
 0.991
prp-21
Yeast PRP (Splicing factor) related.
   
 
 0.974
F53H1.1
Uncharacterized protein.
   
 
 0.963
cdc-5L
Cell Division Cycle related.
   
 
 0.961
T13H5.4
Matrin-type domain-containing protein.
   
 
 0.960
Y82E9BR.2
Uncharacterized protein.
   
 
 0.934
uaf-2
U2AF splicing factor.
 
 
 
 0.927
ZK1098.1
WW domain-containing protein ZK1098.1.
    
 
 0.923
rde-12
DEAD-box ATP-dependent RNA helicase rde-12; Probable ATP-dependent RNA helicase involved in RNAi-mediated gene silencing. Specifically required in the endogenous siRNA pathway for biogenesis of secondary endogenous small interfering RNA (siRNA) intermediates called 22G-RNAs. May associate with and recruit rde- 10 to primary siRNA-targeted mRNA for secondary siRNA synthesis. May be recruited to target mRNAs by rde-1 and/or ergo-1.
   
 
 0.906
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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