STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rec-1Uncharacterized protein. (369 aa)    
Predicted Functional Partners:
xnd-1
X chromosome NonDisjunction factor.
   
  
 0.816
rmh-1
DUF1767 domain-containing protein.
   
  
 0.717
hgap-1
Rap-GAP domain-containing protein.
      
 0.697
him-14
MutS protein homolog him-14; Required during the pachytene stage of meiotic prophase for the formation of crossovers between homologous chromosomes. Not needed for pairing or synapsis. May promote crossing over by interfering with Holliday junction branch migration. Has no apparent role in DNA mismatch repair.
   
  
 0.606
him-6
Bloom syndrome protein homolog; Participates in DNA replication and repair (By similarity). Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (By similarity). Negatively regulates sister chromatid exchange (SCE) ; Belongs to the helicase family. RecQ subfamily.
   
  
 0.547
slx-1
Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA (Potential). Has a preference for replication forks over 5' flap structures or Holliday junctions and shows much lower activity toward 3' flap structures. Required for proper crossover distribution through inhibition of crossover formation at the c [...]
   
  
 0.533
zhp-4
Zip (Yeast meiotic zipper) Homologous Protein.
   
  
 0.503
spo-11
Meiotic recombination protein spo-11; Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination.
   
  
 0.438
cosa-1
CrossOver Site Associated.
   
  
 0.407
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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