node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aak-2 | crh-1 | T01C8.1b.1 | Y41C4A.4g.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...] | BZIP domain-containing protein. | 0.510 |
aak-2 | crtc-1 | T01C8.1b.1 | Y20F4.2.2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...] | CREB-regulated transcription coactivator 1 homolog; Transcriptional coactivator for crh-1, the homolog of vertebrate transcription factor CREB1. Regulates the transcription of metabolic genes and may have a role in mitochondrial dynamics and metabolism. Through crh-1, counteracts the pro-lifespan-extension signals of AMPK both cell autonomously and, when expressed in neurons, at a systemic level, possibly using the catecholamine analog, octopamine, as a messenger ; Belongs to the TORC family. | 0.784 |
aak-2 | ftt-2 | T01C8.1b.1 | F52D10.3a.3 | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...] | 14-3-3-like protein 2; Required for extension of life-span by sir-2.1. Promotes nuclear export of yap-1. Negatively regulates the transcriptional activity of daf-16 by sequestering it to the cytoplasm. Belongs to the 14-3-3 family. | 0.465 |
aak-2 | par-5 | T01C8.1b.1 | M117.2a.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...] | 14-3-3-like protein 1. | 0.539 |
aak-2 | tax-6 | T01C8.1b.1 | C02F4.2b.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...] | Serine/threonine-protein phosphatase 2B catalytic subunit; Calcium-dependent, calmodulin-stimulated protein phosphatase. Dephosphorylates arrd-17. Dephosphorylates daf-16 at 'Ser-319' which regulates daf-16 nuclear translocation. Dephosphorylates calcium permeable cation channel pkd-2 at 'Ser-534'. Regulates male mating behavior including response to hermaphrodite contact and vulva location and localization of pkd-2 to neuronal cilium. Negatively regulates several sensory behaviors including thermotaxis in ADF neurons, osmosensation in ASH neurons, olfaction adaptation in AWC neurons a [...] | 0.409 |
crh-1 | aak-2 | Y41C4A.4g.1 | T01C8.1b.1 | BZIP domain-containing protein. | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...] | 0.510 |
crh-1 | crtc-1 | Y41C4A.4g.1 | Y20F4.2.2 | BZIP domain-containing protein. | CREB-regulated transcription coactivator 1 homolog; Transcriptional coactivator for crh-1, the homolog of vertebrate transcription factor CREB1. Regulates the transcription of metabolic genes and may have a role in mitochondrial dynamics and metabolism. Through crh-1, counteracts the pro-lifespan-extension signals of AMPK both cell autonomously and, when expressed in neurons, at a systemic level, possibly using the catecholamine analog, octopamine, as a messenger ; Belongs to the TORC family. | 0.889 |
crh-1 | tax-6 | Y41C4A.4g.1 | C02F4.2b.1 | BZIP domain-containing protein. | Serine/threonine-protein phosphatase 2B catalytic subunit; Calcium-dependent, calmodulin-stimulated protein phosphatase. Dephosphorylates arrd-17. Dephosphorylates daf-16 at 'Ser-319' which regulates daf-16 nuclear translocation. Dephosphorylates calcium permeable cation channel pkd-2 at 'Ser-534'. Regulates male mating behavior including response to hermaphrodite contact and vulva location and localization of pkd-2 to neuronal cilium. Negatively regulates several sensory behaviors including thermotaxis in ADF neurons, osmosensation in ASH neurons, olfaction adaptation in AWC neurons a [...] | 0.581 |
crtc-1 | aak-2 | Y20F4.2.2 | T01C8.1b.1 | CREB-regulated transcription coactivator 1 homolog; Transcriptional coactivator for crh-1, the homolog of vertebrate transcription factor CREB1. Regulates the transcription of metabolic genes and may have a role in mitochondrial dynamics and metabolism. Through crh-1, counteracts the pro-lifespan-extension signals of AMPK both cell autonomously and, when expressed in neurons, at a systemic level, possibly using the catecholamine analog, octopamine, as a messenger ; Belongs to the TORC family. | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...] | 0.784 |
crtc-1 | crh-1 | Y20F4.2.2 | Y41C4A.4g.1 | CREB-regulated transcription coactivator 1 homolog; Transcriptional coactivator for crh-1, the homolog of vertebrate transcription factor CREB1. Regulates the transcription of metabolic genes and may have a role in mitochondrial dynamics and metabolism. Through crh-1, counteracts the pro-lifespan-extension signals of AMPK both cell autonomously and, when expressed in neurons, at a systemic level, possibly using the catecholamine analog, octopamine, as a messenger ; Belongs to the TORC family. | BZIP domain-containing protein. | 0.889 |
crtc-1 | ftt-2 | Y20F4.2.2 | F52D10.3a.3 | CREB-regulated transcription coactivator 1 homolog; Transcriptional coactivator for crh-1, the homolog of vertebrate transcription factor CREB1. Regulates the transcription of metabolic genes and may have a role in mitochondrial dynamics and metabolism. Through crh-1, counteracts the pro-lifespan-extension signals of AMPK both cell autonomously and, when expressed in neurons, at a systemic level, possibly using the catecholamine analog, octopamine, as a messenger ; Belongs to the TORC family. | 14-3-3-like protein 2; Required for extension of life-span by sir-2.1. Promotes nuclear export of yap-1. Negatively regulates the transcriptional activity of daf-16 by sequestering it to the cytoplasm. Belongs to the 14-3-3 family. | 0.483 |
crtc-1 | hcf-1 | Y20F4.2.2 | C46A5.9.1 | CREB-regulated transcription coactivator 1 homolog; Transcriptional coactivator for crh-1, the homolog of vertebrate transcription factor CREB1. Regulates the transcription of metabolic genes and may have a role in mitochondrial dynamics and metabolism. Through crh-1, counteracts the pro-lifespan-extension signals of AMPK both cell autonomously and, when expressed in neurons, at a systemic level, possibly using the catecholamine analog, octopamine, as a messenger ; Belongs to the TORC family. | Host cell factor 1. | 0.421 |
crtc-1 | par-5 | Y20F4.2.2 | M117.2a.1 | CREB-regulated transcription coactivator 1 homolog; Transcriptional coactivator for crh-1, the homolog of vertebrate transcription factor CREB1. Regulates the transcription of metabolic genes and may have a role in mitochondrial dynamics and metabolism. Through crh-1, counteracts the pro-lifespan-extension signals of AMPK both cell autonomously and, when expressed in neurons, at a systemic level, possibly using the catecholamine analog, octopamine, as a messenger ; Belongs to the TORC family. | 14-3-3-like protein 1. | 0.419 |
crtc-1 | tax-6 | Y20F4.2.2 | C02F4.2b.1 | CREB-regulated transcription coactivator 1 homolog; Transcriptional coactivator for crh-1, the homolog of vertebrate transcription factor CREB1. Regulates the transcription of metabolic genes and may have a role in mitochondrial dynamics and metabolism. Through crh-1, counteracts the pro-lifespan-extension signals of AMPK both cell autonomously and, when expressed in neurons, at a systemic level, possibly using the catecholamine analog, octopamine, as a messenger ; Belongs to the TORC family. | Serine/threonine-protein phosphatase 2B catalytic subunit; Calcium-dependent, calmodulin-stimulated protein phosphatase. Dephosphorylates arrd-17. Dephosphorylates daf-16 at 'Ser-319' which regulates daf-16 nuclear translocation. Dephosphorylates calcium permeable cation channel pkd-2 at 'Ser-534'. Regulates male mating behavior including response to hermaphrodite contact and vulva location and localization of pkd-2 to neuronal cilium. Negatively regulates several sensory behaviors including thermotaxis in ADF neurons, osmosensation in ASH neurons, olfaction adaptation in AWC neurons a [...] | 0.701 |
ftt-2 | aak-2 | F52D10.3a.3 | T01C8.1b.1 | 14-3-3-like protein 2; Required for extension of life-span by sir-2.1. Promotes nuclear export of yap-1. Negatively regulates the transcriptional activity of daf-16 by sequestering it to the cytoplasm. Belongs to the 14-3-3 family. | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...] | 0.465 |
ftt-2 | crtc-1 | F52D10.3a.3 | Y20F4.2.2 | 14-3-3-like protein 2; Required for extension of life-span by sir-2.1. Promotes nuclear export of yap-1. Negatively regulates the transcriptional activity of daf-16 by sequestering it to the cytoplasm. Belongs to the 14-3-3 family. | CREB-regulated transcription coactivator 1 homolog; Transcriptional coactivator for crh-1, the homolog of vertebrate transcription factor CREB1. Regulates the transcription of metabolic genes and may have a role in mitochondrial dynamics and metabolism. Through crh-1, counteracts the pro-lifespan-extension signals of AMPK both cell autonomously and, when expressed in neurons, at a systemic level, possibly using the catecholamine analog, octopamine, as a messenger ; Belongs to the TORC family. | 0.483 |
ftt-2 | hcf-1 | F52D10.3a.3 | C46A5.9.1 | 14-3-3-like protein 2; Required for extension of life-span by sir-2.1. Promotes nuclear export of yap-1. Negatively regulates the transcriptional activity of daf-16 by sequestering it to the cytoplasm. Belongs to the 14-3-3 family. | Host cell factor 1. | 0.748 |
ftt-2 | par-5 | F52D10.3a.3 | M117.2a.1 | 14-3-3-like protein 2; Required for extension of life-span by sir-2.1. Promotes nuclear export of yap-1. Negatively regulates the transcriptional activity of daf-16 by sequestering it to the cytoplasm. Belongs to the 14-3-3 family. | 14-3-3-like protein 1. | 0.658 |
ftt-2 | tax-6 | F52D10.3a.3 | C02F4.2b.1 | 14-3-3-like protein 2; Required for extension of life-span by sir-2.1. Promotes nuclear export of yap-1. Negatively regulates the transcriptional activity of daf-16 by sequestering it to the cytoplasm. Belongs to the 14-3-3 family. | Serine/threonine-protein phosphatase 2B catalytic subunit; Calcium-dependent, calmodulin-stimulated protein phosphatase. Dephosphorylates arrd-17. Dephosphorylates daf-16 at 'Ser-319' which regulates daf-16 nuclear translocation. Dephosphorylates calcium permeable cation channel pkd-2 at 'Ser-534'. Regulates male mating behavior including response to hermaphrodite contact and vulva location and localization of pkd-2 to neuronal cilium. Negatively regulates several sensory behaviors including thermotaxis in ADF neurons, osmosensation in ASH neurons, olfaction adaptation in AWC neurons a [...] | 0.469 |
hcf-1 | crtc-1 | C46A5.9.1 | Y20F4.2.2 | Host cell factor 1. | CREB-regulated transcription coactivator 1 homolog; Transcriptional coactivator for crh-1, the homolog of vertebrate transcription factor CREB1. Regulates the transcription of metabolic genes and may have a role in mitochondrial dynamics and metabolism. Through crh-1, counteracts the pro-lifespan-extension signals of AMPK both cell autonomously and, when expressed in neurons, at a systemic level, possibly using the catecholamine analog, octopamine, as a messenger ; Belongs to the TORC family. | 0.421 |