node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
T25B9.1 | Y37E11AM.2 | T25B9.1.1 | Y37E11AM.2b.1 | Aminotran_1_2 domain-containing protein. | Uncharacterized protein. | 0.493 |
T25B9.1 | fath-1 | T25B9.1.1 | C25A1.5.1 | Aminotran_1_2 domain-containing protein. | Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] | 0.511 |
Y37E11AM.2 | T25B9.1 | Y37E11AM.2b.1 | T25B9.1.1 | Uncharacterized protein. | Aminotran_1_2 domain-containing protein. | 0.493 |
Y37E11AM.2 | cerk-1 | Y37E11AM.2b.1 | T10B11.2.1 | Uncharacterized protein. | Ceramide kinase 1; Catalyzes the phosphorylation of ceramide to form ceramide 1- phosphate. | 0.477 |
Y37E11AM.2 | fath-1 | Y37E11AM.2b.1 | C25A1.5.1 | Uncharacterized protein. | Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] | 0.615 |
Y37E11AM.2 | hyl-1 | Y37E11AM.2b.1 | C09G4.1b.1 | Uncharacterized protein. | Ceramide synthase hyl-1; Catalyzes the acylation of sphingosine to form ceramides. Exhibits substrate preference for fatty acyl-coA chains containing 24 and 26 carbons. | 0.447 |
Y37E11AM.2 | hyl-2 | Y37E11AM.2b.1 | K02G10.6.1 | Uncharacterized protein. | Ceramide synthase hyl-2; Catalyzes the acylation of sphingosine to form ceramides. Exhibits substrate preference for fatty acyl-coA chains containing 20 and 22 carbons. Required for adaptation of the nematode to anoxia. Anoxia tolerance may require one or more of the ceramide species that are either specifically or preferentially synthesized by hyl-2, and seems to be effected by a pathway that is parallel to that involving daf-2. | 0.447 |
Y37E11AM.2 | lagr-1 | Y37E11AM.2b.1 | Y6B3B.10.1 | Uncharacterized protein. | Probable ceramide synthase lagr-1; Catalyzes the acylation of sphingosine to form ceramides. | 0.447 |
Y37E11AM.2 | sptl-1 | Y37E11AM.2b.1 | C23H3.4a.2 | Uncharacterized protein. | Serine palmitoyltransferase 1; Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen. | 0.823 |
Y37E11AM.2 | sptl-2 | Y37E11AM.2b.1 | F43H9.2b.1 | Uncharacterized protein. | Serine palmitoyltransferase 2; Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | 0.600 |
Y37E11AM.2 | sptl-3 | Y37E11AM.2b.1 | T22G5.5b.1 | Uncharacterized protein. | Serine palmitoyltransferase 3; Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | 0.594 |
cerk-1 | Y37E11AM.2 | T10B11.2.1 | Y37E11AM.2b.1 | Ceramide kinase 1; Catalyzes the phosphorylation of ceramide to form ceramide 1- phosphate. | Uncharacterized protein. | 0.477 |
cerk-1 | fath-1 | T10B11.2.1 | C25A1.5.1 | Ceramide kinase 1; Catalyzes the phosphorylation of ceramide to form ceramide 1- phosphate. | Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] | 0.426 |
cerk-1 | hyl-1 | T10B11.2.1 | C09G4.1b.1 | Ceramide kinase 1; Catalyzes the phosphorylation of ceramide to form ceramide 1- phosphate. | Ceramide synthase hyl-1; Catalyzes the acylation of sphingosine to form ceramides. Exhibits substrate preference for fatty acyl-coA chains containing 24 and 26 carbons. | 0.927 |
cerk-1 | hyl-2 | T10B11.2.1 | K02G10.6.1 | Ceramide kinase 1; Catalyzes the phosphorylation of ceramide to form ceramide 1- phosphate. | Ceramide synthase hyl-2; Catalyzes the acylation of sphingosine to form ceramides. Exhibits substrate preference for fatty acyl-coA chains containing 20 and 22 carbons. Required for adaptation of the nematode to anoxia. Anoxia tolerance may require one or more of the ceramide species that are either specifically or preferentially synthesized by hyl-2, and seems to be effected by a pathway that is parallel to that involving daf-2. | 0.967 |
cerk-1 | lagr-1 | T10B11.2.1 | Y6B3B.10.1 | Ceramide kinase 1; Catalyzes the phosphorylation of ceramide to form ceramide 1- phosphate. | Probable ceramide synthase lagr-1; Catalyzes the acylation of sphingosine to form ceramides. | 0.940 |
cerk-1 | sptl-1 | T10B11.2.1 | C23H3.4a.2 | Ceramide kinase 1; Catalyzes the phosphorylation of ceramide to form ceramide 1- phosphate. | Serine palmitoyltransferase 1; Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen. | 0.903 |
cerk-1 | sptl-2 | T10B11.2.1 | F43H9.2b.1 | Ceramide kinase 1; Catalyzes the phosphorylation of ceramide to form ceramide 1- phosphate. | Serine palmitoyltransferase 2; Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | 0.833 |
cerk-1 | sptl-3 | T10B11.2.1 | T22G5.5b.1 | Ceramide kinase 1; Catalyzes the phosphorylation of ceramide to form ceramide 1- phosphate. | Serine palmitoyltransferase 3; Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | 0.743 |
fath-1 | T25B9.1 | C25A1.5.1 | T25B9.1.1 | Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] | Aminotran_1_2 domain-containing protein. | 0.511 |