node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
W03G9.8 | air-1 | W03G9.8.1 | K07C11.2.2 | Mitotic spindle organiZing protein (MOZART) homolog. | Protein kinase domain-containing protein. | 0.685 |
W03G9.8 | spd-5 | W03G9.8.1 | F56A3.4.1 | Mitotic spindle organiZing protein (MOZART) homolog. | Spindle-defective protein 5; Plays a central role in centrosome maturation and mitotic spindle assembly during the first division of the zygote. Required for the centrosomal localization of air-1 and zyg-9. Probably not required in late embryogenesis and during larval development. | 0.695 |
W03G9.8 | tac-1 | W03G9.8.1 | Y54E2A.3.1 | Mitotic spindle organiZing protein (MOZART) homolog. | Transforming acid coiled-coil-containing protein 1; Involved in microtubule formation, polymerization and assembly, regulating microtubule nucleation and length. Plays a role in pronuclear migration and mitotic and meiotic spindle elongation during early embryogenesis. In complex with zyg-9, functions during the early stages of embryonic development to regulate microtubule assembly throughout the cell cycle. Specifically, the complex is required for the formation and growth of astral microtubules and spindle microtubules during mitotic spindle assembly. At anaphase, the complex is requ [...] | 0.762 |
W03G9.8 | tpxl-1 | W03G9.8.1 | Y39G10AR.12a.1 | Mitotic spindle organiZing protein (MOZART) homolog. | TPX2 (Targeting Protein for Xenopus Klp2)-Like. | 0.745 |
W03G9.8 | zyg-9 | W03G9.8.1 | F22B5.7.1 | Mitotic spindle organiZing protein (MOZART) homolog. | Zygote defective protein 9; Plays a major role in organizing microtubules and spindle poles during mitosis and meiosis in one-cell stage embryos. Required for default nucleus positioning in oocytes. | 0.669 |
air-1 | W03G9.8 | K07C11.2.2 | W03G9.8.1 | Protein kinase domain-containing protein. | Mitotic spindle organiZing protein (MOZART) homolog. | 0.685 |
air-1 | plk-1 | K07C11.2.2 | C14B9.4b.1 | Protein kinase domain-containing protein. | Serine/threonine-protein kinase plk-1; Required for oocyte nuclear envelope breakdown before entry of oocyte into spermatheca. In meiotic cells, required for spindle dynamics and probably for spindle attachment to the chromosomes. Zygotic role in the development of the germline and nerve cord. In mitotic cells, plays a role in spindle organization and centrosome maturation. Involved in asymmetric nuclear localization of cdc- 25.1 during embryogenesis which affects cell division timing. Together with plk- 2, regulates cytoplasm polarity in early embryos. May play a minor role in chromos [...] | 0.954 |
air-1 | rsa-1 | K07C11.2.2 | C25A1.9a.1 | Protein kinase domain-containing protein. | Serine/threonine-protein phosphatase 2A regulatory subunit rsa-1; Regulatory subunit of phosphatase let-92 which recruits let- 92/paa-1 complex to the centrosomes, thereby regulating microtubule outgrowth from centrosomes and mitotic spindle assembly ensuring the stability of kinetochore microtubules. | 0.738 |
air-1 | rsa-2 | K07C11.2.2 | Y48A6B.11b.1 | Protein kinase domain-containing protein. | Regulator of spindle assembly protein 2; Recruits rsa-1 and, thereby, phosphatase let-92/paa-1 complex to the centrosomes. Recruits sys-1/beta-catenin to mitotic centrosomes during the first embryonic cell divisions. | 0.761 |
air-1 | saps-1 | K07C11.2.2 | C47G2.5c.1 | Protein kinase domain-containing protein. | Serine/threonine-protein phosphatase 6 regulatory subunit; Regulatory subunit of protein phosphatase 6 (PP6) (Probable). In complex with pph-6, promotes actomyosin contractility during cytokinesis by regulating the organization of cortical non-muscle myosin II nmy-2 and thus contributing to correct spindle positioning. Also required for the proper generation of pulling forces on spindle poles during anaphase by regulating the cortical localization of gpr-1, gpr-2 and lin-5. Negatively regulates kinase air-1 localization at the cell cortex ; Belongs to the SAPS family. | 0.507 |
air-1 | spd-2 | K07C11.2.2 | F32H2.3.1 | Protein kinase domain-containing protein. | Spindle-defective protein 2; Required both for centrosome duplication and maturation. Required for pericentriolar material (PCM) recruitment. | 0.845 |
air-1 | spd-5 | K07C11.2.2 | F56A3.4.1 | Protein kinase domain-containing protein. | Spindle-defective protein 5; Plays a central role in centrosome maturation and mitotic spindle assembly during the first division of the zygote. Required for the centrosomal localization of air-1 and zyg-9. Probably not required in late embryogenesis and during larval development. | 0.914 |
air-1 | tac-1 | K07C11.2.2 | Y54E2A.3.1 | Protein kinase domain-containing protein. | Transforming acid coiled-coil-containing protein 1; Involved in microtubule formation, polymerization and assembly, regulating microtubule nucleation and length. Plays a role in pronuclear migration and mitotic and meiotic spindle elongation during early embryogenesis. In complex with zyg-9, functions during the early stages of embryonic development to regulate microtubule assembly throughout the cell cycle. Specifically, the complex is required for the formation and growth of astral microtubules and spindle microtubules during mitotic spindle assembly. At anaphase, the complex is requ [...] | 0.943 |
air-1 | tpxl-1 | K07C11.2.2 | Y39G10AR.12a.1 | Protein kinase domain-containing protein. | TPX2 (Targeting Protein for Xenopus Klp2)-Like. | 0.967 |
air-1 | zyg-9 | K07C11.2.2 | F22B5.7.1 | Protein kinase domain-containing protein. | Zygote defective protein 9; Plays a major role in organizing microtubules and spindle poles during mitosis and meiosis in one-cell stage embryos. Required for default nucleus positioning in oocytes. | 0.899 |
plk-1 | air-1 | C14B9.4b.1 | K07C11.2.2 | Serine/threonine-protein kinase plk-1; Required for oocyte nuclear envelope breakdown before entry of oocyte into spermatheca. In meiotic cells, required for spindle dynamics and probably for spindle attachment to the chromosomes. Zygotic role in the development of the germline and nerve cord. In mitotic cells, plays a role in spindle organization and centrosome maturation. Involved in asymmetric nuclear localization of cdc- 25.1 during embryogenesis which affects cell division timing. Together with plk- 2, regulates cytoplasm polarity in early embryos. May play a minor role in chromos [...] | Protein kinase domain-containing protein. | 0.954 |
plk-1 | rsa-1 | C14B9.4b.1 | C25A1.9a.1 | Serine/threonine-protein kinase plk-1; Required for oocyte nuclear envelope breakdown before entry of oocyte into spermatheca. In meiotic cells, required for spindle dynamics and probably for spindle attachment to the chromosomes. Zygotic role in the development of the germline and nerve cord. In mitotic cells, plays a role in spindle organization and centrosome maturation. Involved in asymmetric nuclear localization of cdc- 25.1 during embryogenesis which affects cell division timing. Together with plk- 2, regulates cytoplasm polarity in early embryos. May play a minor role in chromos [...] | Serine/threonine-protein phosphatase 2A regulatory subunit rsa-1; Regulatory subunit of phosphatase let-92 which recruits let- 92/paa-1 complex to the centrosomes, thereby regulating microtubule outgrowth from centrosomes and mitotic spindle assembly ensuring the stability of kinetochore microtubules. | 0.631 |
plk-1 | rsa-2 | C14B9.4b.1 | Y48A6B.11b.1 | Serine/threonine-protein kinase plk-1; Required for oocyte nuclear envelope breakdown before entry of oocyte into spermatheca. In meiotic cells, required for spindle dynamics and probably for spindle attachment to the chromosomes. Zygotic role in the development of the germline and nerve cord. In mitotic cells, plays a role in spindle organization and centrosome maturation. Involved in asymmetric nuclear localization of cdc- 25.1 during embryogenesis which affects cell division timing. Together with plk- 2, regulates cytoplasm polarity in early embryos. May play a minor role in chromos [...] | Regulator of spindle assembly protein 2; Recruits rsa-1 and, thereby, phosphatase let-92/paa-1 complex to the centrosomes. Recruits sys-1/beta-catenin to mitotic centrosomes during the first embryonic cell divisions. | 0.694 |
plk-1 | spd-2 | C14B9.4b.1 | F32H2.3.1 | Serine/threonine-protein kinase plk-1; Required for oocyte nuclear envelope breakdown before entry of oocyte into spermatheca. In meiotic cells, required for spindle dynamics and probably for spindle attachment to the chromosomes. Zygotic role in the development of the germline and nerve cord. In mitotic cells, plays a role in spindle organization and centrosome maturation. Involved in asymmetric nuclear localization of cdc- 25.1 during embryogenesis which affects cell division timing. Together with plk- 2, regulates cytoplasm polarity in early embryos. May play a minor role in chromos [...] | Spindle-defective protein 2; Required both for centrosome duplication and maturation. Required for pericentriolar material (PCM) recruitment. | 0.977 |
plk-1 | spd-5 | C14B9.4b.1 | F56A3.4.1 | Serine/threonine-protein kinase plk-1; Required for oocyte nuclear envelope breakdown before entry of oocyte into spermatheca. In meiotic cells, required for spindle dynamics and probably for spindle attachment to the chromosomes. Zygotic role in the development of the germline and nerve cord. In mitotic cells, plays a role in spindle organization and centrosome maturation. Involved in asymmetric nuclear localization of cdc- 25.1 during embryogenesis which affects cell division timing. Together with plk- 2, regulates cytoplasm polarity in early embryos. May play a minor role in chromos [...] | Spindle-defective protein 5; Plays a central role in centrosome maturation and mitotic spindle assembly during the first division of the zygote. Required for the centrosomal localization of air-1 and zyg-9. Probably not required in late embryogenesis and during larval development. | 0.970 |