STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
set-23Probable histone-lysine N-methyltransferase set-23; Probable histone methyltransferase (By similarity). Required for embryonic development; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (244 aa)    
Predicted Functional Partners:
set-27
SET domain-containing protein.
      
 0.894
set-22
SET domain-containing protein.
   
  
 0.855
set-24
SET (Trithorax/polycomb) domain containing.
   
 
 0.834
B0564.2
Fe2OG dioxygenase domain-containing protein.
   
  
 0.819
set-17
SET domain-containing protein.
   
 
 0.733
prp-19
Pre-mRNA-processing factor 19; Probable ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Core component of the NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity (By similarity). Together with emb-4, necessary for interaction of rnp-4, a probable exon junction complex component, with mRNAs and spliceosomal snRNAs. Plays a role in nuclear retention of unspliced mRNAs. Belongs to the WD repeat PRP19 family.
   
 
 0.723
set-19
SET domain-containing protein.
      
 0.550
ced-2
Cell death abnormality protein 2; Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Has a role in the migration of the 2 gonadal distal tip cells (DTCs).
 
 
    0.526
set-26
Histone-lysine N-methyltransferase set-26; Histone methyltransferase that mediates trimethylation of 'Lys-9' of histone H3 in vitro. Involved in transcriptional regulation. Plays a role in the negative regulation of lifespan and in heat resistance. Together with set-9, negatively regulates lifespan in a germline-independent, partially daf-16-dependent fashion. Together with set-9, plays a role in germline development and maintenance and might play a role in the restriction of the trimethylation mark on histone H3 'Lys-4'(H3K4me3) to target genes specifically in the germline. Together w [...]
    
 
 0.522
set-18
MYND-type domain-containing protein.
      
 0.481
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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