STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
set-24SET (Trithorax/polycomb) domain containing. (868 aa)    
Predicted Functional Partners:
set-27
SET domain-containing protein.
      
 0.914
set-11
SET (Trithorax/polycomb) domain containing.
    
 
 0.843
set-23
Probable histone-lysine N-methyltransferase set-23; Probable histone methyltransferase (By similarity). Required for embryonic development; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
   
 
 0.834
set-18
MYND-type domain-containing protein.
    
 
 0.793
utx-1
UTX (Ubiquitously transcribed TPR on X) homolog.
   
 
 0.711
mrpl-2
Ribosomal_L2_C domain-containing protein.
   
 
 0.710
set-17
SET domain-containing protein.
   
  
 0.708
cwp-5
Coexpressed With Polycystins.
   
 
 0.693
mrps-14
Probable 40S ribosomal protein S14, mitochondrial; Belongs to the universal ribosomal protein uS14 family.
   
 
 0.688
sin-3
Paired amphipathic helix protein sin-3; Probable transcriptional repressor required for the deposition of dimethylated 'Lys-9' of histone H3 (H3K9me2) on asynapsed chromosome pairs (both autosomes and sex chromosomes) during meiosis, but this does not seem to solely affect the transcriptional status. Plays a role in ray fusion and patterning in the male tail, and this may be through activity of the histone deacetylase complex (HDAC).
   
 
 0.683
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.