node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
air-1 | ebp-1 | K07C11.2.2 | Y59A8B.7.1 | Protein kinase domain-containing protein. | Microtubule End Binding Protein. | 0.581 |
air-1 | klp-7 | K07C11.2.2 | K11D9.1a.1 | Protein kinase domain-containing protein. | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.897 |
air-1 | let-92 | K07C11.2.2 | F38H4.9.2 | Protein kinase domain-containing protein. | Serine/threonine-protein phosphatase 2A catalytic subunit; Protein phosphatase which plays an essential role in early embryonic cell division. Probably together with constant regulatory subunit paa-1 and regulatory subunit sur-6, positively regulates centriole duplication by preventing the degradation of sas-5 and kinase zyg-1. In addition, plays a role in the recruitment of sas- 6 and maybe sas-5 to centrioles and may dephosphorylate sas-5 and zyg-1 negative regulator szy-20. During vulva development, may play a role with regulatory subunits paa-1 and sur-6 in the induction of vulva c [...] | 0.428 |
air-1 | plk-1 | K07C11.2.2 | C14B9.4b.1 | Protein kinase domain-containing protein. | Serine/threonine-protein kinase plk-1; Required for oocyte nuclear envelope breakdown before entry of oocyte into spermatheca. In meiotic cells, required for spindle dynamics and probably for spindle attachment to the chromosomes. Zygotic role in the development of the germline and nerve cord. In mitotic cells, plays a role in spindle organization and centrosome maturation. Involved in asymmetric nuclear localization of cdc- 25.1 during embryogenesis which affects cell division timing. Together with plk- 2, regulates cytoplasm polarity in early embryos. May play a minor role in chromos [...] | 0.954 |
air-1 | rsa-1 | K07C11.2.2 | C25A1.9a.1 | Protein kinase domain-containing protein. | Serine/threonine-protein phosphatase 2A regulatory subunit rsa-1; Regulatory subunit of phosphatase let-92 which recruits let- 92/paa-1 complex to the centrosomes, thereby regulating microtubule outgrowth from centrosomes and mitotic spindle assembly ensuring the stability of kinetochore microtubules. | 0.738 |
air-1 | rsa-2 | K07C11.2.2 | Y48A6B.11b.1 | Protein kinase domain-containing protein. | Regulator of spindle assembly protein 2; Recruits rsa-1 and, thereby, phosphatase let-92/paa-1 complex to the centrosomes. Recruits sys-1/beta-catenin to mitotic centrosomes during the first embryonic cell divisions. | 0.761 |
air-1 | spd-2 | K07C11.2.2 | F32H2.3.1 | Protein kinase domain-containing protein. | Spindle-defective protein 2; Required both for centrosome duplication and maturation. Required for pericentriolar material (PCM) recruitment. | 0.845 |
air-1 | spd-5 | K07C11.2.2 | F56A3.4.1 | Protein kinase domain-containing protein. | Spindle-defective protein 5; Plays a central role in centrosome maturation and mitotic spindle assembly during the first division of the zygote. Required for the centrosomal localization of air-1 and zyg-9. Probably not required in late embryogenesis and during larval development. | 0.914 |
air-1 | tac-1 | K07C11.2.2 | Y54E2A.3.1 | Protein kinase domain-containing protein. | Transforming acid coiled-coil-containing protein 1; Involved in microtubule formation, polymerization and assembly, regulating microtubule nucleation and length. Plays a role in pronuclear migration and mitotic and meiotic spindle elongation during early embryogenesis. In complex with zyg-9, functions during the early stages of embryonic development to regulate microtubule assembly throughout the cell cycle. Specifically, the complex is required for the formation and growth of astral microtubules and spindle microtubules during mitotic spindle assembly. At anaphase, the complex is requ [...] | 0.943 |
air-1 | tpxl-1 | K07C11.2.2 | Y39G10AR.12a.1 | Protein kinase domain-containing protein. | TPX2 (Targeting Protein for Xenopus Klp2)-Like. | 0.967 |
ebp-1 | air-1 | Y59A8B.7.1 | K07C11.2.2 | Microtubule End Binding Protein. | Protein kinase domain-containing protein. | 0.581 |
ebp-1 | klp-7 | Y59A8B.7.1 | K11D9.1a.1 | Microtubule End Binding Protein. | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.779 |
ebp-1 | rsa-2 | Y59A8B.7.1 | Y48A6B.11b.1 | Microtubule End Binding Protein. | Regulator of spindle assembly protein 2; Recruits rsa-1 and, thereby, phosphatase let-92/paa-1 complex to the centrosomes. Recruits sys-1/beta-catenin to mitotic centrosomes during the first embryonic cell divisions. | 0.742 |
klp-7 | air-1 | K11D9.1a.1 | K07C11.2.2 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Protein kinase domain-containing protein. | 0.897 |
klp-7 | ebp-1 | K11D9.1a.1 | Y59A8B.7.1 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Microtubule End Binding Protein. | 0.779 |
klp-7 | plk-1 | K11D9.1a.1 | C14B9.4b.1 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Serine/threonine-protein kinase plk-1; Required for oocyte nuclear envelope breakdown before entry of oocyte into spermatheca. In meiotic cells, required for spindle dynamics and probably for spindle attachment to the chromosomes. Zygotic role in the development of the germline and nerve cord. In mitotic cells, plays a role in spindle organization and centrosome maturation. Involved in asymmetric nuclear localization of cdc- 25.1 during embryogenesis which affects cell division timing. Together with plk- 2, regulates cytoplasm polarity in early embryos. May play a minor role in chromos [...] | 0.657 |
klp-7 | rsa-1 | K11D9.1a.1 | C25A1.9a.1 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Serine/threonine-protein phosphatase 2A regulatory subunit rsa-1; Regulatory subunit of phosphatase let-92 which recruits let- 92/paa-1 complex to the centrosomes, thereby regulating microtubule outgrowth from centrosomes and mitotic spindle assembly ensuring the stability of kinetochore microtubules. | 0.624 |
klp-7 | rsa-2 | K11D9.1a.1 | Y48A6B.11b.1 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Regulator of spindle assembly protein 2; Recruits rsa-1 and, thereby, phosphatase let-92/paa-1 complex to the centrosomes. Recruits sys-1/beta-catenin to mitotic centrosomes during the first embryonic cell divisions. | 0.705 |
klp-7 | spd-2 | K11D9.1a.1 | F32H2.3.1 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Spindle-defective protein 2; Required both for centrosome duplication and maturation. Required for pericentriolar material (PCM) recruitment. | 0.487 |
klp-7 | spd-5 | K11D9.1a.1 | F56A3.4.1 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Spindle-defective protein 5; Plays a central role in centrosome maturation and mitotic spindle assembly during the first division of the zygote. Required for the centrosomal localization of air-1 and zyg-9. Probably not required in late embryogenesis and during larval development. | 0.563 |