node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ace-3 | acr-16 | Y48B6A.8.1 | F25G6.3.1 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Acetylcholine receptor subunit alpha-type acr-16; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (By similarity). A subunit of the levamisole-insensitive nicotinic receptor. | 0.684 |
ace-3 | cha-1 | Y48B6A.8.1 | ZC416.8b.1 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses (By similarity). Required in SIA sublateral cholinergic motor neurons for a left-right turning behavior that occurs during the lethargus phase of the normal sleep process called 'flipping'. During 'flipping' animals rotate 180 degrees about their longitudinal axis ; Belongs to the carnitine/choline acetyltransferase family. | 0.601 |
ace-3 | droe-4 | Y48B6A.8.1 | F58E10.7.1 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Dietary restriction over expressed. | 0.663 |
ace-3 | molo-1 | Y48B6A.8.1 | F09F7.1.1 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Uncharacterized protein. | 0.587 |
ace-3 | ric-3 | Y48B6A.8.1 | T14A8.1.1 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Resistance to inhibitors of cholinesterase protein 3; Required for maturation and cell surface expression of acetylcholine receptors; Belongs to the ric-3 family. | 0.825 |
ace-3 | ric-8 | Y48B6A.8.1 | Y69A2AR.2a.1 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Synembryn; Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins independently of G-protein coupled receptors. Acts by exchanging bound GDP for free GTP. Able to facilitate synaptic transmission in the nervous system probably by activating G(q)-alpha (egl-30). Also able to activate the G(s)-alpha in synaptic signaling network. Plays a key role in asymmetric spindle positioning, a step for asymmetric cell division that generates cell diversity during development by activating G(i)-alpha protein goa-1 and gpa-16 independently of G-protein couple [...] | 0.669 |
ace-3 | rig-3 | Y48B6A.8.1 | C53B7.1.1 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Neuronal immunoglobulin domain-containing protein rig-3; Cell surface protein which plays a role in the plasticity of cholinergic synapses at neuromuscular junctions and in the polarity of the mechanosensory neuron ALM, possibly by antagonizing Wnt signaling. | 0.498 |
ace-3 | slo-1 | Y48B6A.8.1 | Y51A2D.19d.1 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Calcium-activated potassium channel slo-1; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Essential for the regulation of neurotransmitter release at synapses. | 0.517 |
ace-3 | unc-17 | Y48B6A.8.1 | ZC416.8a.1 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Vesicular acetylcholine transporter unc-17; Involved in acetylcholine transport into synaptic vesicles. Belongs to the major facilitator superfamily. Vesicular transporter family. | 0.736 |
ace-3 | unc-63 | Y48B6A.8.1 | Y110A7A.3.1 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Acetylcholine receptor subunit alpha-type unc-63; Alpha subunit of nicotinic acetylcholine receptor (nAChR). Probably acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion. Involved in nAChR sensitivity to nicotine and levamisole. | 0.485 |
acr-16 | ace-3 | F25G6.3.1 | Y48B6A.8.1 | Acetylcholine receptor subunit alpha-type acr-16; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (By similarity). A subunit of the levamisole-insensitive nicotinic receptor. | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | 0.684 |
acr-16 | ric-3 | F25G6.3.1 | T14A8.1.1 | Acetylcholine receptor subunit alpha-type acr-16; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (By similarity). A subunit of the levamisole-insensitive nicotinic receptor. | Resistance to inhibitors of cholinesterase protein 3; Required for maturation and cell surface expression of acetylcholine receptors; Belongs to the ric-3 family. | 0.943 |
acr-16 | unc-17 | F25G6.3.1 | ZC416.8a.1 | Acetylcholine receptor subunit alpha-type acr-16; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (By similarity). A subunit of the levamisole-insensitive nicotinic receptor. | Vesicular acetylcholine transporter unc-17; Involved in acetylcholine transport into synaptic vesicles. Belongs to the major facilitator superfamily. Vesicular transporter family. | 0.658 |
cha-1 | ace-3 | ZC416.8b.1 | Y48B6A.8.1 | Choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses (By similarity). Required in SIA sublateral cholinergic motor neurons for a left-right turning behavior that occurs during the lethargus phase of the normal sleep process called 'flipping'. During 'flipping' animals rotate 180 degrees about their longitudinal axis ; Belongs to the carnitine/choline acetyltransferase family. | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | 0.601 |
cha-1 | unc-17 | ZC416.8b.1 | ZC416.8a.1 | Choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses (By similarity). Required in SIA sublateral cholinergic motor neurons for a left-right turning behavior that occurs during the lethargus phase of the normal sleep process called 'flipping'. During 'flipping' animals rotate 180 degrees about their longitudinal axis ; Belongs to the carnitine/choline acetyltransferase family. | Vesicular acetylcholine transporter unc-17; Involved in acetylcholine transport into synaptic vesicles. Belongs to the major facilitator superfamily. Vesicular transporter family. | 0.974 |
droe-4 | ace-3 | F58E10.7.1 | Y48B6A.8.1 | Dietary restriction over expressed. | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | 0.663 |
molo-1 | ace-3 | F09F7.1.1 | Y48B6A.8.1 | Uncharacterized protein. | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | 0.587 |
molo-1 | ric-3 | F09F7.1.1 | T14A8.1.1 | Uncharacterized protein. | Resistance to inhibitors of cholinesterase protein 3; Required for maturation and cell surface expression of acetylcholine receptors; Belongs to the ric-3 family. | 0.704 |
molo-1 | unc-63 | F09F7.1.1 | Y110A7A.3.1 | Uncharacterized protein. | Acetylcholine receptor subunit alpha-type unc-63; Alpha subunit of nicotinic acetylcholine receptor (nAChR). Probably acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion. Involved in nAChR sensitivity to nicotine and levamisole. | 0.540 |
ric-3 | ace-3 | T14A8.1.1 | Y48B6A.8.1 | Resistance to inhibitors of cholinesterase protein 3; Required for maturation and cell surface expression of acetylcholine receptors; Belongs to the ric-3 family. | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | 0.825 |