STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
flp-18FMRFamide-like neuropeptide 18; Together with flp-1, plays a homeostatic role by acting on the GABAergic neural transmission at neuromuscular junctions to prevent overexcitation of the locomotor circuit. Plays a role in the navigational capacity of sperm and the targeting of sperm derived from males to the fertilization site in the uterus of hermaphrodites. [EMPGVLRF-amide]: Inhibits the activity of dissected pharyngeal myogenic muscle system. (208 aa)    
Predicted Functional Partners:
npr-1
G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.
   
 
 0.984
npr-5
G_PROTEIN_RECEP_F1_2 domain-containing protein.
   
 
 0.979
npr-4
G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.
   
 
 0.976
flp-14
FMRFamide-like neuropeptides 14; FMRFamides and FMRFamide-like peptides are neuropeptides. KHEYLRF-amide has an excitatory effect on dissected pharyngeal myogenic muscle system. Functions in RID peptidergic neurons to promote forward locomotory behavior.
   
  
 0.940
flp-21
FMRF-Like Peptide.
   
  
 0.929
flp-12
FMRFamide-like peptide 12.
   
  
 0.905
flp-11
FMRFamide-like neuropeptides 11; FMRFamides and FMRFamide-like peptides are neuropeptides. [ASGGMRNALVRF-amide]: Acts as a ligand for the npr-22 receptor in vitro; Belongs to the FARP (FMRFamide related peptide) family.
   
  
 0.890
flp-7
FMRFamide-like neuropeptides 7; FMRFamides and FMRFamide-like peptides are neuropeptides. flp-7 stimulates serotonin-induced fat loss by binding to and activating the npr-22 receptor which leads to induction of the atgl-1 lipase and subsequent fat loss. SPMQRSSMVRF-amide: Acts as a ligand for the npr-22 receptor in vitro. [SPMDRSKMVRF-amide]: Acts as a ligand for the npr-22 receptor in vitro.
   
  
 0.874
flp-6
FMRFamide-like neuropeptides 6; FMRFamides and FMRFamide-like peptides are neuropeptides. KSAYMRF-amide has an excitatory effect on dissected pharyngeal myogenic muscle system; Belongs to the FARP (FMRFamide related peptide) family.
   
 
 0.853
flp-13
FMRFamide-like neuropeptides 13; FMRFamides and FMRFamide-like peptides are neuropeptides. APEASPFIRF-amide: Inhibits muscle tension in somatic muscle. Potent inhibitor of the activity of the dissected pharyngeal myogenic muscle system. [SPSAVPLIRF-amide]: Acts as a ligand for the npr-22 receptor in vitro. [ASSAPLIRF-amide]: Acts as a ligand for the npr-22 receptor in vitro; Belongs to the FARP (FMRFamide related peptide) family.
   
  
 0.853
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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