node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Y48G8AL.5 | herc-1 | Y48G8AL.5a.1 | Y48G8AL.1a.1 | SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | HECT domain-containing protein. | 0.829 |
atg-7 | herc-1 | M7.5.1 | Y48G8AL.1a.1 | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy. | HECT domain-containing protein. | 0.631 |
atg-7 | rpn-10 | M7.5.1 | B0205.3.2 | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy. | 26S proteasome non-ATPase regulatory subunit 4; Binds and presumably selects ubiquitin-conjugates for destruction (By similarity). Required for protein degradation and ubiquitin-proteasome system (UBS) function and regulates proteasomal subunit expression. Involvement in UBS might be cell type specific. Regulator of the autophagy-lysosome pathway that may confer resistance to autophagy by regulating the expression of autophagy-related proteins such as lgg-1, and by regulating lysosome formation, possibly by modulating elt-2 activity. Required for fertility, sperm production, and sex de [...] | 0.735 |
atg-7 | uba-1 | M7.5.1 | C47E12.5a.2 | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy. | UBA_e1_C domain-containing protein; Belongs to the ubiquitin-activating E1 family. | 0.860 |
atg-7 | ubc-13 | M7.5.1 | Y54G2A.31.1 | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy. | Ubiquitin-conjugating enzyme E2 13; Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own. The uev-1-ubc-13 heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. Involved in sorting Lys-63-linked polyubiquitinated maternal membrane proteins for degradation by targeting to multivesicular bodies. May be involved in the ubiquitination and growth of intracellular polyglutamine protein aggregates. May have a role in AMPA-type glutamate receptor trafficking in neurons. | 0.631 |
atg-7 | ubc-18 | M7.5.1 | R01H2.6.1 | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy. | UBIQUITIN_CONJUGAT_2 domain-containing protein. | 0.678 |
atg-7 | ubc-22 | M7.5.1 | C06E2.7.1 | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy. | UBiquitin Conjugating enzyme. | 0.631 |
atg-7 | ubq-1 | M7.5.1 | F25B5.4a.2 | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy. | Ubiquitin-related; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degrad [...] | 0.632 |
drh-3 | herc-1 | D2005.5.1 | Y48G8AL.1a.1 | Dicer Related Helicase. | HECT domain-containing protein. | 0.628 |
drh-3 | uba-1 | D2005.5.1 | C47E12.5a.2 | Dicer Related Helicase. | UBA_e1_C domain-containing protein; Belongs to the ubiquitin-activating E1 family. | 0.599 |
drh-3 | ubc-18 | D2005.5.1 | R01H2.6.1 | Dicer Related Helicase. | UBIQUITIN_CONJUGAT_2 domain-containing protein. | 0.594 |
drh-3 | ubc-22 | D2005.5.1 | C06E2.7.1 | Dicer Related Helicase. | UBiquitin Conjugating enzyme. | 0.452 |
drh-3 | ubq-1 | D2005.5.1 | F25B5.4a.2 | Dicer Related Helicase. | Ubiquitin-related; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degrad [...] | 0.596 |
herc-1 | Y48G8AL.5 | Y48G8AL.1a.1 | Y48G8AL.5a.1 | HECT domain-containing protein. | SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | 0.829 |
herc-1 | atg-7 | Y48G8AL.1a.1 | M7.5.1 | HECT domain-containing protein. | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy. | 0.631 |
herc-1 | drh-3 | Y48G8AL.1a.1 | D2005.5.1 | HECT domain-containing protein. | Dicer Related Helicase. | 0.628 |
herc-1 | mage-1 | Y48G8AL.1a.1 | F40E3.2.1 | HECT domain-containing protein. | Melanoma-Associated-antiGEn homolog. | 0.658 |
herc-1 | rpn-10 | Y48G8AL.1a.1 | B0205.3.2 | HECT domain-containing protein. | 26S proteasome non-ATPase regulatory subunit 4; Binds and presumably selects ubiquitin-conjugates for destruction (By similarity). Required for protein degradation and ubiquitin-proteasome system (UBS) function and regulates proteasomal subunit expression. Involvement in UBS might be cell type specific. Regulator of the autophagy-lysosome pathway that may confer resistance to autophagy by regulating the expression of autophagy-related proteins such as lgg-1, and by regulating lysosome formation, possibly by modulating elt-2 activity. Required for fertility, sperm production, and sex de [...] | 0.764 |
herc-1 | uba-1 | Y48G8AL.1a.1 | C47E12.5a.2 | HECT domain-containing protein. | UBA_e1_C domain-containing protein; Belongs to the ubiquitin-activating E1 family. | 0.719 |
herc-1 | ubc-13 | Y48G8AL.1a.1 | Y54G2A.31.1 | HECT domain-containing protein. | Ubiquitin-conjugating enzyme E2 13; Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own. The uev-1-ubc-13 heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. Involved in sorting Lys-63-linked polyubiquitinated maternal membrane proteins for degradation by targeting to multivesicular bodies. May be involved in the ubiquitination and growth of intracellular polyglutamine protein aggregates. May have a role in AMPA-type glutamate receptor trafficking in neurons. | 0.659 |