STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gcn-1TOG domain-containing protein. (2651 aa)    
Predicted Functional Partners:
abcf-3
ABC transporter, class F.
   
 
 0.996
gcn-2
Eukaryotic translation initiation factor 2-alpha kinase gcn-2; Serine/threonine-protein kinase which phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (eIF2alpha), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis (By similarity). Involved in the unfolded protein response (UPR) triggered by several stresses including mitochondrial, osmotic and oxidative stresses, amino acid deprivation and UV irradiation, probably by phosphorylating and inhibiting eIF2alpha. In addition, leads to [...]
   
 
 0.973
rpl-19
60S ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family.
 
 
   0.942
C02F5.3
Uncharacterized GTP-binding protein C02F5.3; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
   
 
 0.938
rps-13
40S ribosomal protein S13; Belongs to the universal ribosomal protein uS15 family.
   
 
 0.915
rps-15
40S ribosomal protein S15; Negatively regulates lifespan.
   
 
 0.912
rps-2
40S ribosomal protein S2; Belongs to the universal ribosomal protein uS5 family.
   
 
 0.908
rps-3
40S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family.
   
 
 0.906
eif-2alpha
S1 motif domain-containing protein.
   
  
 0.904
rps-9
40S ribosomal protein S9; Belongs to the universal ribosomal protein uS4 family.
   
 
 0.897
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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