node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C31C9.2 | dhfr-1 | C31C9.2.1 | C36B1.7.1 | Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Putative dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | 0.552 |
C31C9.2 | gcsh-1 | C31C9.2.1 | D1025.2.1 | Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.761 |
C31C9.2 | gcsh-2 | C31C9.2.1 | F52A8.5.2 | Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.761 |
C31C9.2 | impt-1 | C31C9.2.1 | Y52B11A.2a.1 | Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Protein IMPACT homolog; Translational regulator that ensures constant high levels of translation under amino acid starvation. Plays a role as a negative regulator of the gcn-2 kinase activity; impairs gcn-1-mediated gcn-2 activation, and hence gcn-2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis in amino acid-starved cells. Plays a role in differentiation of neuronal cells by stimulating neurite outgrowth; Belongs to the IMPACT family. | 0.823 |
atx-2 | impt-1 | D2045.1d.1 | Y52B11A.2a.1 | Ataxin-2 homolog; Probable RNA-binding protein that negatively regulates the translation of targets. Functions with RNA-binding protein szy-20 to ensure embryonic cell division, and to this end, plays a role in the regulation of centrosome assembly, position and size, and in astral microtubule outgrowth and nucleation. Required for gonad development, germ cell proliferation and for the production of oocytes. Regulates whole body growth and fat accumulation in response to food availability, and this may be through the mTOR pathway, upstream of daf-15 and rheb-1. Belongs to the ataxin-2 [...] | Protein IMPACT homolog; Translational regulator that ensures constant high levels of translation under amino acid starvation. Plays a role as a negative regulator of the gcn-2 kinase activity; impairs gcn-1-mediated gcn-2 activation, and hence gcn-2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis in amino acid-starved cells. Plays a role in differentiation of neuronal cells by stimulating neurite outgrowth; Belongs to the IMPACT family. | 0.747 |
ctbp-1 | dhfr-1 | F49E10.5a.1 | C36B1.7.1 | C-terminal-binding protein 1; Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism. | Putative dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | 0.552 |
ctbp-1 | gcsh-1 | F49E10.5a.1 | D1025.2.1 | C-terminal-binding protein 1; Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism. | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.757 |
ctbp-1 | gcsh-2 | F49E10.5a.1 | F52A8.5.2 | C-terminal-binding protein 1; Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism. | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.757 |
ctbp-1 | impt-1 | F49E10.5a.1 | Y52B11A.2a.1 | C-terminal-binding protein 1; Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism. | Protein IMPACT homolog; Translational regulator that ensures constant high levels of translation under amino acid starvation. Plays a role as a negative regulator of the gcn-2 kinase activity; impairs gcn-1-mediated gcn-2 activation, and hence gcn-2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis in amino acid-starved cells. Plays a role in differentiation of neuronal cells by stimulating neurite outgrowth; Belongs to the IMPACT family. | 0.823 |
dhfr-1 | C31C9.2 | C36B1.7.1 | C31C9.2.1 | Putative dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.552 |
dhfr-1 | ctbp-1 | C36B1.7.1 | F49E10.5a.1 | Putative dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | C-terminal-binding protein 1; Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism. | 0.552 |
dhfr-1 | dtmk-1 | C36B1.7.1 | R53.2.2 | Putative dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP. | 0.954 |
dhfr-1 | dut-1 | C36B1.7.1 | K07A1.2.3 | Putative dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | Deoxyuridinetriphosphatase. | 0.861 |
dhfr-1 | gcsh-1 | C36B1.7.1 | D1025.2.1 | Putative dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.937 |
dhfr-1 | gcsh-2 | C36B1.7.1 | F52A8.5.2 | Putative dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.860 |
dhfr-1 | impt-1 | C36B1.7.1 | Y52B11A.2a.1 | Putative dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | Protein IMPACT homolog; Translational regulator that ensures constant high levels of translation under amino acid starvation. Plays a role as a negative regulator of the gcn-2 kinase activity; impairs gcn-1-mediated gcn-2 activation, and hence gcn-2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis in amino acid-starved cells. Plays a role in differentiation of neuronal cells by stimulating neurite outgrowth; Belongs to the IMPACT family. | 0.826 |
dhfr-1 | thk-1 | C36B1.7.1 | Y43C5A.5a.1 | Putative dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | Thymidine kinase. | 0.961 |
dtmk-1 | dhfr-1 | R53.2.2 | C36B1.7.1 | Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP. | Putative dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | 0.954 |
dtmk-1 | dut-1 | R53.2.2 | K07A1.2.3 | Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP. | Deoxyuridinetriphosphatase. | 0.992 |
dtmk-1 | impt-1 | R53.2.2 | Y52B11A.2a.1 | Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP. | Protein IMPACT homolog; Translational regulator that ensures constant high levels of translation under amino acid starvation. Plays a role as a negative regulator of the gcn-2 kinase activity; impairs gcn-1-mediated gcn-2 activation, and hence gcn-2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis in amino acid-starved cells. Plays a role in differentiation of neuronal cells by stimulating neurite outgrowth; Belongs to the IMPACT family. | 0.868 |