node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C18E9.2 | dnj-29 | C18E9.2a.1 | Y63D3A.6b.2 | Uncharacterized protein. | J domain-containing protein. | 0.999 |
C18E9.2 | emo-1 | C18E9.2a.1 | F32D8.6.1 | Uncharacterized protein. | Protein transport protein Sec61 subunit gamma; Required for oocyte development and ovulation. Required for the translocation of secretory and transmembrane proteins into the endoplasmic reticulum in vitro ; Belongs to the SecE/SEC61-gamma family. | 0.985 |
C18E9.2 | strd-1 | C18E9.2a.1 | Y52D3.1a.1 | Uncharacterized protein. | STE20-related kinase adapter protein strd-1; Pseudokinase which may act as an adapter for kinases sad-1 and par-4 and thereby is involved in several developmental processes. Regulates cell-autonomously both neuronal polarity and synaptic organization when bound to sad-1. Required for sad-1 localization to synapses. Required to establish germline stem cell (GSC) quiescence during dauer development, to promote cell shedding during embryogenesis and to control asymmetric cell division of the Q.p neuroblast lineage, probably when bound to par-4. May be involved in maintaining the integrity [...] | 0.918 |
aak-1 | aak-2 | PAR2.3a.2 | T01C8.1b.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1; Probably does not act as a sensor that couples lifespan to information about energy levels and insulin-like signals. Together with aak-2, involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...] | 0.910 |
aak-1 | mop-25.1 | PAR2.3a.2 | R02E12.2a.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1; Probably does not act as a sensor that couples lifespan to information about energy levels and insulin-like signals. Together with aak-2, involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. | MO25 (MOuse embryo scaffolding Protein) homolog. | 0.924 |
aak-1 | mop-25.2 | PAR2.3a.2 | Y53C12A.4.2 | 5'-AMP-activated protein kinase catalytic subunit alpha-1; Probably does not act as a sensor that couples lifespan to information about energy levels and insulin-like signals. Together with aak-2, involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. | MO25-like protein 2; Regulates asymmetric cell division in Q.p neuroblast lineage. Plays a role in cell shedding during embryogenesis. | 0.926 |
aak-1 | par-4 | PAR2.3a.2 | Y59A8B.14a.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1; Probably does not act as a sensor that couples lifespan to information about energy levels and insulin-like signals. Together with aak-2, involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. | Serine/threonine-protein kinase par-4; Required for cytoplasmic partitioning and asymmetric cell division in early embryogenesis. Controls the asymmetric cell division of the Q.p neuroblast lineage. Involved in mediating cell polarization via regulation of anillin family scaffold proteins. Phosphorylates and restricts the asymmetry effectors mex-5 and mex-6 to the anterior cytoplasm of the zygote and maintains these phosphorylations until fertilization. May phosphorylate par-1. Required for strd-1 localization to the cell cortex of early embryos and may be required for strd-1 protein s [...] | 0.959 |
aak-1 | slr-2 | PAR2.3a.2 | Y59A8B.13a.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1; Probably does not act as a sensor that couples lifespan to information about energy levels and insulin-like signals. Together with aak-2, involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. | Synthetic with Lin-35/Rb. | 0.459 |
aak-1 | strd-1 | PAR2.3a.2 | Y52D3.1a.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1; Probably does not act as a sensor that couples lifespan to information about energy levels and insulin-like signals. Together with aak-2, involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. | STE20-related kinase adapter protein strd-1; Pseudokinase which may act as an adapter for kinases sad-1 and par-4 and thereby is involved in several developmental processes. Regulates cell-autonomously both neuronal polarity and synaptic organization when bound to sad-1. Required for sad-1 localization to synapses. Required to establish germline stem cell (GSC) quiescence during dauer development, to promote cell shedding during embryogenesis and to control asymmetric cell division of the Q.p neuroblast lineage, probably when bound to par-4. May be involved in maintaining the integrity [...] | 0.935 |
aak-2 | aak-1 | T01C8.1b.1 | PAR2.3a.2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...] | 5'-AMP-activated protein kinase catalytic subunit alpha-1; Probably does not act as a sensor that couples lifespan to information about energy levels and insulin-like signals. Together with aak-2, involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. | 0.910 |
aak-2 | mop-25.1 | T01C8.1b.1 | R02E12.2a.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...] | MO25 (MOuse embryo scaffolding Protein) homolog. | 0.927 |
aak-2 | mop-25.2 | T01C8.1b.1 | Y53C12A.4.2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...] | MO25-like protein 2; Regulates asymmetric cell division in Q.p neuroblast lineage. Plays a role in cell shedding during embryogenesis. | 0.924 |
aak-2 | par-4 | T01C8.1b.1 | Y59A8B.14a.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...] | Serine/threonine-protein kinase par-4; Required for cytoplasmic partitioning and asymmetric cell division in early embryogenesis. Controls the asymmetric cell division of the Q.p neuroblast lineage. Involved in mediating cell polarization via regulation of anillin family scaffold proteins. Phosphorylates and restricts the asymmetry effectors mex-5 and mex-6 to the anterior cytoplasm of the zygote and maintains these phosphorylations until fertilization. May phosphorylate par-1. Required for strd-1 localization to the cell cortex of early embryos and may be required for strd-1 protein s [...] | 0.957 |
aak-2 | slr-2 | T01C8.1b.1 | Y59A8B.13a.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...] | Synthetic with Lin-35/Rb. | 0.459 |
aak-2 | strd-1 | T01C8.1b.1 | Y52D3.1a.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...] | STE20-related kinase adapter protein strd-1; Pseudokinase which may act as an adapter for kinases sad-1 and par-4 and thereby is involved in several developmental processes. Regulates cell-autonomously both neuronal polarity and synaptic organization when bound to sad-1. Required for sad-1 localization to synapses. Required to establish germline stem cell (GSC) quiescence during dauer development, to promote cell shedding during embryogenesis and to control asymmetric cell division of the Q.p neuroblast lineage, probably when bound to par-4. May be involved in maintaining the integrity [...] | 0.930 |
dnj-29 | C18E9.2 | Y63D3A.6b.2 | C18E9.2a.1 | J domain-containing protein. | Uncharacterized protein. | 0.999 |
dnj-29 | emo-1 | Y63D3A.6b.2 | F32D8.6.1 | J domain-containing protein. | Protein transport protein Sec61 subunit gamma; Required for oocyte development and ovulation. Required for the translocation of secretory and transmembrane proteins into the endoplasmic reticulum in vitro ; Belongs to the SecE/SEC61-gamma family. | 0.995 |
dnj-29 | strd-1 | Y63D3A.6b.2 | Y52D3.1a.1 | J domain-containing protein. | STE20-related kinase adapter protein strd-1; Pseudokinase which may act as an adapter for kinases sad-1 and par-4 and thereby is involved in several developmental processes. Regulates cell-autonomously both neuronal polarity and synaptic organization when bound to sad-1. Required for sad-1 localization to synapses. Required to establish germline stem cell (GSC) quiescence during dauer development, to promote cell shedding during embryogenesis and to control asymmetric cell division of the Q.p neuroblast lineage, probably when bound to par-4. May be involved in maintaining the integrity [...] | 0.929 |
emo-1 | C18E9.2 | F32D8.6.1 | C18E9.2a.1 | Protein transport protein Sec61 subunit gamma; Required for oocyte development and ovulation. Required for the translocation of secretory and transmembrane proteins into the endoplasmic reticulum in vitro ; Belongs to the SecE/SEC61-gamma family. | Uncharacterized protein. | 0.985 |
emo-1 | dnj-29 | F32D8.6.1 | Y63D3A.6b.2 | Protein transport protein Sec61 subunit gamma; Required for oocyte development and ovulation. Required for the translocation of secretory and transmembrane proteins into the endoplasmic reticulum in vitro ; Belongs to the SecE/SEC61-gamma family. | J domain-containing protein. | 0.995 |