node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F52C6.2 | otub-1 | F52C6.2.1 | C25D7.8.2 | Ubiquitin-like domain-containing protein. | Ubiquitin thioesterase otubain-like; Hydrolase that can remove conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Specifically cleaves 'Lys-48'-linked polyubiquitin. | 0.490 |
F52C6.2 | uba-1 | F52C6.2.1 | C47E12.5a.2 | Ubiquitin-like domain-containing protein. | UBA_e1_C domain-containing protein; Belongs to the ubiquitin-activating E1 family. | 0.987 |
F52C6.2 | ubc-1 | F52C6.2.1 | C35B1.1.1 | Ubiquitin-like domain-containing protein. | Ubiquitin-conjugating enzyme E2 1; Catalyzes the covalent attachment of ubiquitin to other proteins; Belongs to the ubiquitin-conjugating enzyme family. | 0.539 |
F52C6.2 | ubc-13 | F52C6.2.1 | Y54G2A.31.1 | Ubiquitin-like domain-containing protein. | Ubiquitin-conjugating enzyme E2 13; Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own. The uev-1-ubc-13 heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. Involved in sorting Lys-63-linked polyubiquitinated maternal membrane proteins for degradation by targeting to multivesicular bodies. May be involved in the ubiquitination and growth of intracellular polyglutamine protein aggregates. May have a role in AMPA-type glutamate receptor trafficking in neurons. | 0.951 |
F52C6.2 | ubq-2 | F52C6.2.1 | ZK1010.1.1 | Ubiquitin-like domain-containing protein. | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] | 0.885 |
F52C6.2 | uev-1 | F52C6.2.1 | F39B2.2.1 | Ubiquitin-like domain-containing protein. | Ubiquitin-conjugating enzyme E2 variant 1; Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own. The uev-1-ubc-13 heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. Involved in sorting Lys-63-linked polyubiquitinated maternal membrane proteins for degradation by targeting to multivesicular bodies. Required for glr-1-containing glutamate receptor trafficking in neurons. May have a role in synaptic transmission at motorneurons. May be involved in the ubiquitination and growth of intracellular polygluta [...] | 0.856 |
F52C6.3 | Y71F9AL.10 | F52C6.3.1 | Y71F9AL.10.1 | Ubiquitin-like domain-containing protein. | RING-type domain-containing protein. | 0.574 |
F52C6.3 | chn-1 | F52C6.3.1 | T09B4.10.2 | Ubiquitin-like domain-containing protein. | C-term of Hsp70-iNteracting protein (CHIP family). | 0.588 |
F52C6.3 | otub-1 | F52C6.3.1 | C25D7.8.2 | Ubiquitin-like domain-containing protein. | Ubiquitin thioesterase otubain-like; Hydrolase that can remove conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Specifically cleaves 'Lys-48'-linked polyubiquitin. | 0.473 |
F52C6.3 | uba-1 | F52C6.3.1 | C47E12.5a.2 | Ubiquitin-like domain-containing protein. | UBA_e1_C domain-containing protein; Belongs to the ubiquitin-activating E1 family. | 0.934 |
F52C6.3 | ubc-1 | F52C6.3.1 | C35B1.1.1 | Ubiquitin-like domain-containing protein. | Ubiquitin-conjugating enzyme E2 1; Catalyzes the covalent attachment of ubiquitin to other proteins; Belongs to the ubiquitin-conjugating enzyme family. | 0.759 |
F52C6.3 | ubc-13 | F52C6.3.1 | Y54G2A.31.1 | Ubiquitin-like domain-containing protein. | Ubiquitin-conjugating enzyme E2 13; Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own. The uev-1-ubc-13 heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. Involved in sorting Lys-63-linked polyubiquitinated maternal membrane proteins for degradation by targeting to multivesicular bodies. May be involved in the ubiquitination and growth of intracellular polyglutamine protein aggregates. May have a role in AMPA-type glutamate receptor trafficking in neurons. | 0.919 |
F52C6.3 | ubq-1 | F52C6.3.1 | F25B5.4a.2 | Ubiquitin-like domain-containing protein. | Ubiquitin-related; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degrad [...] | 0.486 |
F52C6.3 | ubq-2 | F52C6.3.1 | ZK1010.1.1 | Ubiquitin-like domain-containing protein. | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] | 0.920 |
F52C6.3 | uev-1 | F52C6.3.1 | F39B2.2.1 | Ubiquitin-like domain-containing protein. | Ubiquitin-conjugating enzyme E2 variant 1; Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own. The uev-1-ubc-13 heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. Involved in sorting Lys-63-linked polyubiquitinated maternal membrane proteins for degradation by targeting to multivesicular bodies. Required for glr-1-containing glutamate receptor trafficking in neurons. May have a role in synaptic transmission at motorneurons. May be involved in the ubiquitination and growth of intracellular polygluta [...] | 0.918 |
Y71F9AL.10 | F52C6.3 | Y71F9AL.10.1 | F52C6.3.1 | RING-type domain-containing protein. | Ubiquitin-like domain-containing protein. | 0.574 |
Y71F9AL.10 | ubc-13 | Y71F9AL.10.1 | Y54G2A.31.1 | RING-type domain-containing protein. | Ubiquitin-conjugating enzyme E2 13; Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own. The uev-1-ubc-13 heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. Involved in sorting Lys-63-linked polyubiquitinated maternal membrane proteins for degradation by targeting to multivesicular bodies. May be involved in the ubiquitination and growth of intracellular polyglutamine protein aggregates. May have a role in AMPA-type glutamate receptor trafficking in neurons. | 0.916 |
Y71F9AL.10 | ubq-1 | Y71F9AL.10.1 | F25B5.4a.2 | RING-type domain-containing protein. | Ubiquitin-related; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degrad [...] | 0.574 |
Y71F9AL.10 | ubq-2 | Y71F9AL.10.1 | ZK1010.1.1 | RING-type domain-containing protein. | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] | 0.511 |
chn-1 | F52C6.3 | T09B4.10.2 | F52C6.3.1 | C-term of Hsp70-iNteracting protein (CHIP family). | Ubiquitin-like domain-containing protein. | 0.588 |