STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nft-1Nitrilase and fragile histidine triad fusion protein NitFhit; Cleaves A-5'-PPP-5'A to yield AMP and ADP. (440 aa)    
Predicted Functional Partners:
spds-1
PABS domain-containing protein; Belongs to the spermidine/spermine synthase family.
 
 
 0.892
his-8
Histone H2B 2.
      
 0.816
C34C12.8
GrpE protein homolog, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).
  
 
 0.770
acds-10
ACaD (ACAD, acyl-CoA Dehydrogenase) Sequence homolog.
  
  
 0.762
adsl-1
Adenylosuccinate lyase; Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
  
 
 0.758
Y62E10A.6
NADPH:adrenodoxin oxidoreductase, mitochondrial.
  
 
 0.757
ndx-9
NADH pyrophosphatase; Belongs to the Nudix hydrolase family. NudC subfamily.
    
 0.738
utx-1
UTX (Ubiquitously transcribed TPR on X) homolog.
  
 
 0.728
agxt-1
Serine--pyruvate aminotransferase.
  
 
 0.723
F38B6.4
Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.
   
 
 0.712
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (30%) [HD]