STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aqp-12AQuaPorin or aquaglyceroporin related; Belongs to the MIP/aquaporin (TC 1.A.8) family. (243 aa)    
Predicted Functional Partners:
alh-13
Probable delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
  
 
 0.698
mei-1
Meiotic spindle formation protein mei-1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays. Required specifically for meiotic spindle formation in the female germline; the presence of this protein is inimical to the formation of mitotic spindles. In body wall muscles, regulates organization of myosin thick filaments.
  
 0.681
C10G11.8
AAA domain-containing protein; Belongs to the AAA ATPase family.
  
 
 0.670
rpt-1
26S proteasome regulatory subunit 7; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).
  
 
 0.670
C55B6.1
FGGY_C domain-containing protein.
  
 
 0.670
lex-1
Tat-binding homolog 7; Thought to form a complex that enhances transcription from repetitive DNA sequences by modulating chromatin structure. Belongs to the AAA ATPase family.
  
 
 0.670
rpt-2
Probable 26S proteasome regulatory subunit 4; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). May play a role in the degradation of microtubule severing protein mei-1.
  
 
 0.670
F56F11.4
AAA domain-containing protein; Belongs to the AAA ATPase family.
  
 
 0.670
R11F4.1
Probable glycerol kinase; Belongs to the FGGY kinase family.
  
 
 0.670
T25C8.1
FGGY_N domain-containing protein.
  
 
 0.670
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.