node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C18E9.2 | Y38F2AR.9 | C18E9.2a.1 | Y38F2AR.9.1 | Uncharacterized protein. | Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. | 0.954 |
C18E9.2 | dnj-29 | C18E9.2a.1 | Y63D3A.6b.2 | Uncharacterized protein. | J domain-containing protein. | 0.999 |
C18E9.2 | emo-1 | C18E9.2a.1 | F32D8.6.1 | Uncharacterized protein. | Protein transport protein Sec61 subunit gamma; Required for oocyte development and ovulation. Required for the translocation of secretory and transmembrane proteins into the endoplasmic reticulum in vitro ; Belongs to the SecE/SEC61-gamma family. | 0.985 |
C18E9.2 | gck-3 | C18E9.2a.1 | Y59A8B.23a.1 | Uncharacterized protein. | Germinal center kinase 3; Plays a role in osmotic stress responses by regulating ion homeostasis and by controlling cell volume via the phosphorylation- mediated inhibition of the chloride channel clh-3. In addition, increases gpdh-1 translation upon osmotic stress, likely downstream of wnk-1. Involved in several developmental processes including the tubular formation of the excretory canals, the formation of the intestine and the progression through larval stages. In addition, required for germ line development by controlling meiosis and chromosomal segregation during spermatogenesis. [...] | 0.985 |
C18E9.2 | sec-61 | C18E9.2a.1 | Y57G11C.15a.1 | Uncharacterized protein. | Plug_translocon domain-containing protein. | 0.989 |
Y38F2AR.9 | C18E9.2 | Y38F2AR.9.1 | C18E9.2a.1 | Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. | Uncharacterized protein. | 0.954 |
Y38F2AR.9 | dnj-29 | Y38F2AR.9.1 | Y63D3A.6b.2 | Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. | J domain-containing protein. | 0.995 |
Y38F2AR.9 | emo-1 | Y38F2AR.9.1 | F32D8.6.1 | Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. | Protein transport protein Sec61 subunit gamma; Required for oocyte development and ovulation. Required for the translocation of secretory and transmembrane proteins into the endoplasmic reticulum in vitro ; Belongs to the SecE/SEC61-gamma family. | 0.999 |
Y38F2AR.9 | gck-3 | Y38F2AR.9.1 | Y59A8B.23a.1 | Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. | Germinal center kinase 3; Plays a role in osmotic stress responses by regulating ion homeostasis and by controlling cell volume via the phosphorylation- mediated inhibition of the chloride channel clh-3. In addition, increases gpdh-1 translation upon osmotic stress, likely downstream of wnk-1. Involved in several developmental processes including the tubular formation of the excretory canals, the formation of the intestine and the progression through larval stages. In addition, required for germ line development by controlling meiosis and chromosomal segregation during spermatogenesis. [...] | 0.919 |
Y38F2AR.9 | sec-61 | Y38F2AR.9.1 | Y57G11C.15a.1 | Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. | Plug_translocon domain-containing protein. | 0.999 |
clh-3 | gck-3 | E04F6.11i.1 | Y59A8B.23a.1 | Chloride channel protein clh-3; [Isoform a]: Voltage-gated chloride channel. Insensitive to depolarizing conditioning voltages, requires low voltages for activation, insensitive to chloride levels and has a mild sensitivity to low pH. Channel gating properties are conferred by the cytoplasmic C-terminus. Plays a role in egg laying by modulating hermaphrodite-specific neurons (HSN) excitability and the ovulatory contractions of gap-junction-coupled gonadal sheath cells. When active, may prevent tubular formation of the excretory canals. Activated during oocyte meiotic maturation and by [...] | Germinal center kinase 3; Plays a role in osmotic stress responses by regulating ion homeostasis and by controlling cell volume via the phosphorylation- mediated inhibition of the chloride channel clh-3. In addition, increases gpdh-1 translation upon osmotic stress, likely downstream of wnk-1. Involved in several developmental processes including the tubular formation of the excretory canals, the formation of the intestine and the progression through larval stages. In addition, required for germ line development by controlling meiosis and chromosomal segregation during spermatogenesis. [...] | 0.932 |
clh-3 | kcc-2 | E04F6.11i.1 | H16O14.1d.1 | Chloride channel protein clh-3; [Isoform a]: Voltage-gated chloride channel. Insensitive to depolarizing conditioning voltages, requires low voltages for activation, insensitive to chloride levels and has a mild sensitivity to low pH. Channel gating properties are conferred by the cytoplasmic C-terminus. Plays a role in egg laying by modulating hermaphrodite-specific neurons (HSN) excitability and the ovulatory contractions of gap-junction-coupled gonadal sheath cells. When active, may prevent tubular formation of the excretory canals. Activated during oocyte meiotic maturation and by [...] | K+/Cl-Cotransporter. | 0.477 |
clh-3 | nkcc-1 | E04F6.11i.1 | Y37A1C.1g.1 | Chloride channel protein clh-3; [Isoform a]: Voltage-gated chloride channel. Insensitive to depolarizing conditioning voltages, requires low voltages for activation, insensitive to chloride levels and has a mild sensitivity to low pH. Channel gating properties are conferred by the cytoplasmic C-terminus. Plays a role in egg laying by modulating hermaphrodite-specific neurons (HSN) excitability and the ovulatory contractions of gap-junction-coupled gonadal sheath cells. When active, may prevent tubular formation of the excretory canals. Activated during oocyte meiotic maturation and by [...] | Na-K-Cl Cotransporter homolog. | 0.771 |
clh-3 | wnk-1 | E04F6.11i.1 | C46C2.1n.2 | Chloride channel protein clh-3; [Isoform a]: Voltage-gated chloride channel. Insensitive to depolarizing conditioning voltages, requires low voltages for activation, insensitive to chloride levels and has a mild sensitivity to low pH. Channel gating properties are conferred by the cytoplasmic C-terminus. Plays a role in egg laying by modulating hermaphrodite-specific neurons (HSN) excitability and the ovulatory contractions of gap-junction-coupled gonadal sheath cells. When active, may prevent tubular formation of the excretory canals. Activated during oocyte meiotic maturation and by [...] | Serine/threonine-protein kinase WNK; Serine/threonine-protein kinase which phosphorylates gck-3. Plays a role in osmotic stress responses during which it increases gpdh-1 translation, likely by phosphorylating gck-3. Essential for larval development and the tubular formation of the excretory canals. | 0.743 |
dnj-29 | C18E9.2 | Y63D3A.6b.2 | C18E9.2a.1 | J domain-containing protein. | Uncharacterized protein. | 0.999 |
dnj-29 | Y38F2AR.9 | Y63D3A.6b.2 | Y38F2AR.9.1 | J domain-containing protein. | Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. | 0.995 |
dnj-29 | emo-1 | Y63D3A.6b.2 | F32D8.6.1 | J domain-containing protein. | Protein transport protein Sec61 subunit gamma; Required for oocyte development and ovulation. Required for the translocation of secretory and transmembrane proteins into the endoplasmic reticulum in vitro ; Belongs to the SecE/SEC61-gamma family. | 0.995 |
dnj-29 | gck-3 | Y63D3A.6b.2 | Y59A8B.23a.1 | J domain-containing protein. | Germinal center kinase 3; Plays a role in osmotic stress responses by regulating ion homeostasis and by controlling cell volume via the phosphorylation- mediated inhibition of the chloride channel clh-3. In addition, increases gpdh-1 translation upon osmotic stress, likely downstream of wnk-1. Involved in several developmental processes including the tubular formation of the excretory canals, the formation of the intestine and the progression through larval stages. In addition, required for germ line development by controlling meiosis and chromosomal segregation during spermatogenesis. [...] | 0.929 |
dnj-29 | sec-61 | Y63D3A.6b.2 | Y57G11C.15a.1 | J domain-containing protein. | Plug_translocon domain-containing protein. | 0.997 |
emo-1 | C18E9.2 | F32D8.6.1 | C18E9.2a.1 | Protein transport protein Sec61 subunit gamma; Required for oocyte development and ovulation. Required for the translocation of secretory and transmembrane proteins into the endoplasmic reticulum in vitro ; Belongs to the SecE/SEC61-gamma family. | Uncharacterized protein. | 0.985 |