STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
memi-2MEiosis-to-MItosis transition associated. (345 aa)    
Predicted Functional Partners:
memi-1
MEiosis-to-MItosis transition associated.
   
  
0.999
puf-11
PUM-HD domain-containing protein.
   
    0.846
gsp-3
Serine/threonine-protein phosphatase PP1-gamma; Probable phosphatase which plays a redundant role with gsp-4 in spermatogenesis by regulating sister chromatid segregation during meiosis. In addition, involved in sperm motility by controlling the dynamic disassembly of major sperm proteins (MSP) in the spermatozoan pseudopodium.
      
 0.810
zyg-11
Early embryogenesis protein zyg-11; Acts as target recruitment subunit in the E3 ubiquitin ligase complex zyg-11-cul-2-elc-1. Required for metaphase to anaphase transition and M phase exit at meiosis II. Regulates polarity establishment.
   
  
 0.720
fer-1
Sperm vesicle fusion protein fer-1; Required for the fusion of the membranous organelles (MOs) with the plasma membrane, a process essential in spermiogenesis.
      
 0.664
memi-3
MEiosis-to-MItosis transition associated.
   
  
0.621
kca-1
Kinesin 1 cargo adaptor alternative variant a.
   
    0.615
marc-3
RING-CH-type domain-containing protein.
   
    0.589
Y48G1A.2
Uncharacterized protein.
   
    0.581
egg-1
LDL receptor repeat-containing protein egg-1; Probable receptor which is required for the oocyte-to-zygote transition although its exact function is controversial. Redundantly with egg-2, seems to be required for fertilization probably by promoting the interaction or fusion between sperm and oocyte. Conversely, shown to be dispensable for fertilization but required together with egg-2 for the formation of a continuous and cohesive eggshell chitin layer by maintaining a homogenous distribution of chitin synthase chs-1 at the unfertilized oocyte cell membrane. Appears to recruit or maint [...]
   
    0.576
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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