STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dnj-29J domain-containing protein. (752 aa)    
Predicted Functional Partners:
C18E9.2
Uncharacterized protein.
   
 0.999
sec-61
Plug_translocon domain-containing protein.
   
 
 0.997
emo-1
Protein transport protein Sec61 subunit gamma; Required for oocyte development and ovulation. Required for the translocation of secretory and transmembrane proteins into the endoplasmic reticulum in vitro ; Belongs to the SecE/SEC61-gamma family.
    
 
 0.995
Y38F2AR.9
Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.
    
 
 0.995
hsp-3
Heat shock 70 kDa protein C; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.
  
 
 0.957
hsp-4
Endoplasmic reticulum chaperone BiP homolog; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Required for ER dynamics during the first embryonic cell divisions. Specifically, controls ER transition into sheet-like structures at the onset of mitosis, possibly by regulating homotypic membrane fusion. Belongs to the heat shock protein 70 family.
  
 
 0.955
strd-1
STE20-related kinase adapter protein strd-1; Pseudokinase which may act as an adapter for kinases sad-1 and par-4 and thereby is involved in several developmental processes. Regulates cell-autonomously both neuronal polarity and synaptic organization when bound to sad-1. Required for sad-1 localization to synapses. Required to establish germline stem cell (GSC) quiescence during dauer development, to promote cell shedding during embryogenesis and to control asymmetric cell division of the Q.p neuroblast lineage, probably when bound to par-4. May be involved in maintaining the integrity [...]
   
 
 0.929
gck-3
Germinal center kinase 3; Plays a role in osmotic stress responses by regulating ion homeostasis and by controlling cell volume via the phosphorylation- mediated inhibition of the chloride channel clh-3. In addition, increases gpdh-1 translation upon osmotic stress, likely downstream of wnk-1. Involved in several developmental processes including the tubular formation of the excretory canals, the formation of the intestine and the progression through larval stages. In addition, required for germ line development by controlling meiosis and chromosomal segregation during spermatogenesis. [...]
    
 
 0.929
T14G8.3
Uncharacterized protein.
  
 
 0.851
T24H7.2
Uncharacterized protein.
  
 
 0.842
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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