STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fln-1Calponin-homology (CH) domain-containing protein. (2259 aa)    
Predicted Functional Partners:
act-5
ACTin.
   
 
 0.993
tln-1
Talin.
   
 
 0.980
zyx-1
Zyxin; Functions as both a mechanical stabilizer (via LIM domains) of focal adhesions and as a sensor component for muscle cell damage (via N-terminus). Regulates, stabilizes and maintains posterior lateral mechanosensory (PLM) synaptic branch extension and new synapse formation and growth during larval development.
   
 0.955
deb-1
Vinculin; Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane. Involved in ovulation.
   
 
 0.939
fln-2
FiLamiN (Actin binding protein) homolog.
   
 
0.922
mkk-4
MAP kinase kinase mkk-4; Activity is required in presynaptic neurons, in a dose- dependent manner, for normal presynaptic development and morphology. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord.
    
 0.909
sek-6
Protein kinase domain-containing protein.
    
 0.909
sek-3
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
   
 0.909
F52C6.2
Ubiquitin-like domain-containing protein.
    
 0.904
cpn-4
Calponin-homology (CH) domain-containing protein.
   
  
 0.877
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.