STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pod-1Uncharacterized protein. (1136 aa)    
Predicted Functional Partners:
emb-8
NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
   
  
 0.709
nmy-2
Non-muscle MYosin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
   
  
 0.684
emb-27
Cell division cycle protein 16 homolog; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells. Required for embryonic anterior-posterior axis formation. Plays a role in regulating [...]
   
  
 0.669
act-5
ACTin.
    
 
 0.632
cpg-2
Chondroitin proteoglycan-2; Required for polar body extrusion during cytokinesis in embryo development. Affects cortical granule size. Has roles in meiotic chromosome segregation, osmotic barrier function and polarization in conjunction with cpg-2. Binds chitin.
   
 
 0.615
mel-26
Protein maternal effect lethal 26; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of microtubule severing protein mei-1 after meiosis. Controls degradation of ppfr-1, the regulatory subunit of PP4 complex, after meiosis. In body wall muscles, involved in the organization of myosin thick filaments, likely by regulating the degradation of mei-1 downstream of unc-89. May also activate the TORC1 pathway.
   
 
 0.596
rft-1
Riboflavin transporter rft-1; Riboflavin transporter. Riboflavin transport is Na(+)- independent but pH-sensitive; Belongs to the riboflavin transporter family.
   
  
 0.590
act-2
Actin-2; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
   
 
 0.533
cpg-1
Chondroitin proteoglycan 1; Required for polar body extrusion during cytokinesis in embryo development. Affects cortical granule size. Has roles in meiotic chromosome segregation, osmotic barrier function and polarization in conjunction with cpg-2. Binds chitin.
   
  
 0.509
pod-2
Uncharacterized protein.
   
  
 0.487
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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