node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
E02H1.6 | F25B5.3 | E02H1.6.1 | F25B5.3b.1 | Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and TMP are also good substrates. ATP and dATP are the best phosphate donors. May have a role in nuclear energy homeostasis; Belongs to the adenylate kinase family. AK6 subfamily. | Putative cytosolic 5'-nucleotidase 3. | 0.900 |
E02H1.6 | F38B2.4 | E02H1.6.1 | F38B2.4a.1 | Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and TMP are also good substrates. ATP and dATP are the best phosphate donors. May have a role in nuclear energy homeostasis; Belongs to the adenylate kinase family. AK6 subfamily. | Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. | 0.983 |
E02H1.6 | R07H5.8 | E02H1.6.1 | R07H5.8.1 | Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and TMP are also good substrates. ATP and dATP are the best phosphate donors. May have a role in nuclear energy homeostasis; Belongs to the adenylate kinase family. AK6 subfamily. | PfkB domain-containing protein. | 0.918 |
E02H1.6 | T19B4.3 | E02H1.6.1 | T19B4.3.1 | Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and TMP are also good substrates. ATP and dATP are the best phosphate donors. May have a role in nuclear energy homeostasis; Belongs to the adenylate kinase family. AK6 subfamily. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.910 |
E02H1.6 | adsl-1 | E02H1.6.1 | R06C7.5a.2 | Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and TMP are also good substrates. ATP and dATP are the best phosphate donors. May have a role in nuclear energy homeostasis; Belongs to the adenylate kinase family. AK6 subfamily. | Adenylosuccinate lyase; Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. | 0.981 |
E02H1.6 | ampd-1 | E02H1.6.1 | C34F11.3d.1 | Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and TMP are also good substrates. ATP and dATP are the best phosphate donors. May have a role in nuclear energy homeostasis; Belongs to the adenylate kinase family. AK6 subfamily. | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 0.900 |
E02H1.6 | let-754 | E02H1.6.1 | C29E4.8.2 | Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and TMP are also good substrates. ATP and dATP are the best phosphate donors. May have a role in nuclear energy homeostasis; Belongs to the adenylate kinase family. AK6 subfamily. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. | 0.938 |
E02H1.6 | pde-4 | E02H1.6.1 | R153.1d.1 | Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and TMP are also good substrates. ATP and dATP are the best phosphate donors. May have a role in nuclear energy homeostasis; Belongs to the adenylate kinase family. AK6 subfamily. | Probable 3',5'-cyclic phosphodiesterase pde-4; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Antagonizes dorsal D (DD) motor neuron respecification by reducing levels of cAMP. | 0.900 |
E02H1.6 | pde-6 | E02H1.6.1 | Y95B8A.10a.1 | Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and TMP are also good substrates. ATP and dATP are the best phosphate donors. May have a role in nuclear energy homeostasis; Belongs to the adenylate kinase family. AK6 subfamily. | Probable 3',5'-cyclic phosphodiesterase pde-6; Belongs to the cyclic nucleotide phosphodiesterase family. | 0.900 |
F25B5.3 | E02H1.6 | F25B5.3b.1 | E02H1.6.1 | Putative cytosolic 5'-nucleotidase 3. | Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and TMP are also good substrates. ATP and dATP are the best phosphate donors. May have a role in nuclear energy homeostasis; Belongs to the adenylate kinase family. AK6 subfamily. | 0.900 |
F25B5.3 | F38B2.4 | F25B5.3b.1 | F38B2.4a.1 | Putative cytosolic 5'-nucleotidase 3. | Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. | 0.900 |
F25B5.3 | R07H5.8 | F25B5.3b.1 | R07H5.8.1 | Putative cytosolic 5'-nucleotidase 3. | PfkB domain-containing protein. | 0.908 |
F25B5.3 | T19B4.3 | F25B5.3b.1 | T19B4.3.1 | Putative cytosolic 5'-nucleotidase 3. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.907 |
F25B5.3 | adsl-1 | F25B5.3b.1 | R06C7.5a.2 | Putative cytosolic 5'-nucleotidase 3. | Adenylosuccinate lyase; Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. | 0.902 |
F25B5.3 | ampd-1 | F25B5.3b.1 | C34F11.3d.1 | Putative cytosolic 5'-nucleotidase 3. | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 0.918 |
F25B5.3 | let-754 | F25B5.3b.1 | C29E4.8.2 | Putative cytosolic 5'-nucleotidase 3. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. | 0.912 |
F25B5.3 | pde-4 | F25B5.3b.1 | R153.1d.1 | Putative cytosolic 5'-nucleotidase 3. | Probable 3',5'-cyclic phosphodiesterase pde-4; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Antagonizes dorsal D (DD) motor neuron respecification by reducing levels of cAMP. | 0.908 |
F25B5.3 | pde-6 | F25B5.3b.1 | Y95B8A.10a.1 | Putative cytosolic 5'-nucleotidase 3. | Probable 3',5'-cyclic phosphodiesterase pde-6; Belongs to the cyclic nucleotide phosphodiesterase family. | 0.900 |
F38B2.4 | E02H1.6 | F38B2.4a.1 | E02H1.6.1 | Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. | Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and TMP are also good substrates. ATP and dATP are the best phosphate donors. May have a role in nuclear energy homeostasis; Belongs to the adenylate kinase family. AK6 subfamily. | 0.983 |
F38B2.4 | F25B5.3 | F38B2.4a.1 | F25B5.3b.1 | Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. | Putative cytosolic 5'-nucleotidase 3. | 0.900 |