node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
M4.1 | pis-1 | M4.1b.1 | T13F2.3b.1 | FHA domain-containing protein. | PIS (Pax-2, IA-1/6, Smad-2 interacting protein) homolog. | 0.746 |
M4.1 | zfh-2 | M4.1b.1 | ZC123.3a.1 | FHA domain-containing protein. | Zinc Finger and Homeobox. | 0.742 |
Y46E12BL.2 | zfh-2 | Y46E12BL.2a.1 | ZC123.3a.1 | NUC173 domain-containing protein. | Zinc Finger and Homeobox. | 0.696 |
atx-3 | dpy-22 | F28F8.6.1 | F47A4.2.1 | Ataxin-3 homolog; Acts as chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin- protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription (By simil [...] | Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Functio [...] | 0.669 |
atx-3 | pis-1 | F28F8.6.1 | T13F2.3b.1 | Ataxin-3 homolog; Acts as chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin- protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription (By simil [...] | PIS (Pax-2, IA-1/6, Smad-2 interacting protein) homolog. | 0.693 |
atx-3 | rnt-1 | F28F8.6.1 | B0414.2.2 | Ataxin-3 homolog; Acts as chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin- protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription (By simil [...] | Runt domain-containing protein. | 0.656 |
atx-3 | tbp-1 | F28F8.6.1 | T20B12.2.1 | Ataxin-3 homolog; Acts as chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin- protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription (By simil [...] | TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. | 0.576 |
atx-3 | zfh-2 | F28F8.6.1 | ZC123.3a.1 | Ataxin-3 homolog; Acts as chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin- protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription (By simil [...] | Zinc Finger and Homeobox. | 0.669 |
ceh-100 | ceh-44 | Y38E10A.6b.1 | Y54F10AM.4a.1 | C. Elegans Homeobox. | Homeobox protein cut-like ceh-44; Probable DNA-binding regulatory protein involved in cell-fate specification; Belongs to the CUT homeobox family. | 0.486 |
ceh-100 | zfh-2 | Y38E10A.6b.1 | ZC123.3a.1 | C. Elegans Homeobox. | Zinc Finger and Homeobox. | 0.693 |
ceh-44 | ceh-100 | Y54F10AM.4a.1 | Y38E10A.6b.1 | Homeobox protein cut-like ceh-44; Probable DNA-binding regulatory protein involved in cell-fate specification; Belongs to the CUT homeobox family. | C. Elegans Homeobox. | 0.486 |
ceh-44 | zfh-2 | Y54F10AM.4a.1 | ZC123.3a.1 | Homeobox protein cut-like ceh-44; Probable DNA-binding regulatory protein involved in cell-fate specification; Belongs to the CUT homeobox family. | Zinc Finger and Homeobox. | 0.801 |
dpy-22 | atx-3 | F47A4.2.1 | F28F8.6.1 | Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Functio [...] | Ataxin-3 homolog; Acts as chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin- protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription (By simil [...] | 0.669 |
dpy-22 | pis-1 | F47A4.2.1 | T13F2.3b.1 | Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Functio [...] | PIS (Pax-2, IA-1/6, Smad-2 interacting protein) homolog. | 0.740 |
dpy-22 | rnt-1 | F47A4.2.1 | B0414.2.2 | Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Functio [...] | Runt domain-containing protein. | 0.713 |
dpy-22 | tbp-1 | F47A4.2.1 | T20B12.2.1 | Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Functio [...] | TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. | 0.549 |
dpy-22 | zfh-2 | F47A4.2.1 | ZC123.3a.1 | Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Functio [...] | Zinc Finger and Homeobox. | 0.671 |
nhr-119 | zfh-2 | K12H6.1.1 | ZC123.3a.1 | Nuclear Hormone Receptor family. | Zinc Finger and Homeobox. | 0.695 |
pis-1 | M4.1 | T13F2.3b.1 | M4.1b.1 | PIS (Pax-2, IA-1/6, Smad-2 interacting protein) homolog. | FHA domain-containing protein. | 0.746 |
pis-1 | atx-3 | T13F2.3b.1 | F28F8.6.1 | PIS (Pax-2, IA-1/6, Smad-2 interacting protein) homolog. | Ataxin-3 homolog; Acts as chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin- protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription (By simil [...] | 0.693 |