STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ncx-3Na/Ca eXchangers; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (830 aa)    
Predicted Functional Partners:
ncx-9
Mitochondrial sodium/calcium exchanger protein; Mitochondrial sodium/calcium antiporter that mediates sodium- dependent calcium efflux from mitochondrion, thereby acting as a key regulator of mitochondrion calcium homeostasis (Probable). Required for patterning of neural circuits: functions in the same pathway as RAC- dependent effectors of the unc-6/netrin signaling pathway to set left/ right patterning of the VD/DD GABAergic circuit. Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
      
 0.837
ncx-10
Na/Ca eXchangers; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
      
 0.833
ncx-6
Putative sodium/calcium exchanger 6.
      
 0.832
ncx-8
Na/Ca eXchangers; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
      
 0.773
ncs-7
Neuronal Calcium Sensor family.
      
 0.764
ncx-5
Na/Ca eXchangers; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
   
  
0.745
ncs-6
Neuronal Calcium Sensor family.
      
 0.698
ncx-7
Putative sodium/calcium exchanger 7.
      
 0.665
ncs-5
EF-hand domain-containing protein.
      
 0.660
pmk-1
Mitogen-activated protein kinase pmk-1; Serine/threonine kinase which responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Phosphorylates snk-1 which probably regulates skn-1 nuclear translocation in response to oxidative stress. Probably by activating skn-1, involved in the up- regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacteria infection. Up-regulates expression of gcs-1 in intestinal cells upon arsenite treatment. Functions downstream of the MAPKK sek-1 and the MAPKKK nsy-1 as the MAP kinase [...]
   
    0.594
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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