STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cdk-11.2Cyclin-dependent kinase 11.2; Probable cyclin-dependent kinase whose activity is most likely regulated by the cyclin cyl-1/Cylin-L. Acts partially redundantly with cdk-11.1 to ensure embryonic viability. In contrast to cdk-11.1, not essential for male and female fertility. (668 aa)    
Predicted Functional Partners:
cyl-1
Cyclin L; Belongs to the cyclin family.
   
 
 0.845
cyy-1
Cyclin-Y; In association with pct-1, regulates the trafficking of synaptic vesicle precursors in DA motor neurons by promoting anterograde trafficking to the axon and preventing dynein-dependent trafficking to the dendrite. May also regulate synaptic vesicle trafficking in DD motor neurons and in RIA interneurons. Involved in synapse formation during DD motor neuron remodeling by disassembling ventral presynaptic structures. May activate cdk-5. Belongs to the cyclin family.
   
  
 0.612
ccnk-1
CYCLIN domain-containing protein; Belongs to the cyclin family.
   
 
 0.498
spt-5
Transcription elongation factor SPT5; May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF may enhance transcriptional pausing at sites proximal to the promoter, which may in turn facilitate the assembly of an elongation competent RNA polymerase II complex. Belongs to the SPT5 family.
   
 
 0.492
ensa-1
ENdoSulfine Alpha; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family.
   
  
 0.484
cyh-1
CYclin H.
   
 
 0.431
tra-4
TRAnsformer: XX animals transformed into males.
   
    0.403
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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