node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
mex-1 | mex-3 | W03C9.7a.1 | F53G12.5b.1 | Muscle EXcess. | Muscle EXcess. | 0.863 |
mex-1 | mex-5 | W03C9.7a.1 | W02A2.7.1 | Muscle EXcess. | Zinc finger protein mex-5; Functions with mex-6 to affect embryonic viability, establish soma germline asymmetry in embryos and establish plk-1, pie-1, mex-1, and pos-1 asymmetry in embryos. Also affects formation of intestinal cells. Binds to mRNA in vitro, and inhibits pgl-3-mediated P-granule formation, probably by competing with pgl-3 for binding to mRNA. | 0.707 |
mex-1 | mex-6 | W03C9.7a.1 | AH6.5.1 | Muscle EXcess. | Zinc finger protein mex-6; Functions with mex-5 to affect embryonic viability, establish soma germline asymmetry in embryos and establish plk-1, pie-1, mex-1, and pos-1 asymmetry in embryos. Also affects formation of intestinal cells. | 0.732 |
mex-1 | nos-2 | W03C9.7a.1 | ZK1127.1.1 | Muscle EXcess. | Nanos-type domain-containing protein; Belongs to the nanos family. | 0.790 |
mex-1 | oma-1 | W03C9.7a.1 | C09G9.6.1 | Muscle EXcess. | CCCH-type zinc finger protein oma-1; Zinc-finger RNA-binding protein that binds to 5'-UA[AU]-3' motifs in the 3'-UTR of maternal mRNAs to suppress translation in oocytes and embryos. Acts as a ribonucleoprotein particle component that may exert part of its function within cytoplasmic foci of unfertilized oocytes. Acts redundantly with oma-2 to control the temporal expression and distribution of maternal proteins and thereby promote meiotic progression, oocyte maturation, fertilization and embryonic development. Recruits the translational repressor ifet-1 to the 3'-UTR of mei-1 and zif- [...] | 0.683 |
mex-1 | oma-2 | W03C9.7a.1 | ZC513.6.1 | Muscle EXcess. | CCCH-type zinc finger protein oma-2; Zinc-finger RNA-binding protein that binds to 5'-UA[AU]-3' motifs in the 3'-UTR of maternal mRNAs to suppress translation in oocytes and embryos. Acts redundantly with oma-1 to control the temporal expression and distribution of maternal proteins and thereby promote meiotic progression, oocyte maturation, fertilization and embryonic development. Also, together with oma-1, is involved in P-granule distribution during embryonic development. | 0.666 |
mex-1 | pie-1 | W03C9.7a.1 | Y49E10.14a.1 | Muscle EXcess. | Pharynx and intestine in excess protein 1; Maternally provided PIE-1 is required for germline cell fate determination. Functions as a repressor of RNA polymerase II-dependent gene expression in the developing germline. Required for expression of nos-2 in P4 germline blastomere cells. Inhibits the histone deacetylase activity of hda-1. Represses transcriptional activation of cdk-9 and cit-1.1, which are members of the P-TEFb complex. | 0.779 |
mex-1 | pos-1 | W03C9.7a.1 | F52E1.1.1 | Muscle EXcess. | Cytoplasmic zinc-finger protein. | 0.661 |
mex-1 | zif-1 | W03C9.7a.1 | F59B2.6.1 | Muscle EXcess. | Zinc finger-interacting factor 1; Probable substrate recognition component of a CBC (Cul2- ElonginB-ElonginC) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Ensures germline precursor cell asymmetry by targeting germline proteins for destruction if expressed in non-germline cells. This process also requires elc-1, cul-2, rbx-1 and ubc-2. | 0.848 |
mex-3 | mex-1 | F53G12.5b.1 | W03C9.7a.1 | Muscle EXcess. | Muscle EXcess. | 0.863 |
mex-3 | mex-5 | F53G12.5b.1 | W02A2.7.1 | Muscle EXcess. | Zinc finger protein mex-5; Functions with mex-6 to affect embryonic viability, establish soma germline asymmetry in embryos and establish plk-1, pie-1, mex-1, and pos-1 asymmetry in embryos. Also affects formation of intestinal cells. Binds to mRNA in vitro, and inhibits pgl-3-mediated P-granule formation, probably by competing with pgl-3 for binding to mRNA. | 0.942 |
mex-3 | mex-6 | F53G12.5b.1 | AH6.5.1 | Muscle EXcess. | Zinc finger protein mex-6; Functions with mex-5 to affect embryonic viability, establish soma germline asymmetry in embryos and establish plk-1, pie-1, mex-1, and pos-1 asymmetry in embryos. Also affects formation of intestinal cells. | 0.936 |
mex-3 | nos-2 | F53G12.5b.1 | ZK1127.1.1 | Muscle EXcess. | Nanos-type domain-containing protein; Belongs to the nanos family. | 0.762 |
mex-3 | oma-1 | F53G12.5b.1 | C09G9.6.1 | Muscle EXcess. | CCCH-type zinc finger protein oma-1; Zinc-finger RNA-binding protein that binds to 5'-UA[AU]-3' motifs in the 3'-UTR of maternal mRNAs to suppress translation in oocytes and embryos. Acts as a ribonucleoprotein particle component that may exert part of its function within cytoplasmic foci of unfertilized oocytes. Acts redundantly with oma-2 to control the temporal expression and distribution of maternal proteins and thereby promote meiotic progression, oocyte maturation, fertilization and embryonic development. Recruits the translational repressor ifet-1 to the 3'-UTR of mei-1 and zif- [...] | 0.920 |
mex-3 | oma-2 | F53G12.5b.1 | ZC513.6.1 | Muscle EXcess. | CCCH-type zinc finger protein oma-2; Zinc-finger RNA-binding protein that binds to 5'-UA[AU]-3' motifs in the 3'-UTR of maternal mRNAs to suppress translation in oocytes and embryos. Acts redundantly with oma-1 to control the temporal expression and distribution of maternal proteins and thereby promote meiotic progression, oocyte maturation, fertilization and embryonic development. Also, together with oma-1, is involved in P-granule distribution during embryonic development. | 0.907 |
mex-3 | pie-1 | F53G12.5b.1 | Y49E10.14a.1 | Muscle EXcess. | Pharynx and intestine in excess protein 1; Maternally provided PIE-1 is required for germline cell fate determination. Functions as a repressor of RNA polymerase II-dependent gene expression in the developing germline. Required for expression of nos-2 in P4 germline blastomere cells. Inhibits the histone deacetylase activity of hda-1. Represses transcriptional activation of cdk-9 and cit-1.1, which are members of the P-TEFb complex. | 0.931 |
mex-3 | pos-1 | F53G12.5b.1 | F52E1.1.1 | Muscle EXcess. | Cytoplasmic zinc-finger protein. | 0.972 |
mex-3 | zif-1 | F53G12.5b.1 | F59B2.6.1 | Muscle EXcess. | Zinc finger-interacting factor 1; Probable substrate recognition component of a CBC (Cul2- ElonginB-ElonginC) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Ensures germline precursor cell asymmetry by targeting germline proteins for destruction if expressed in non-germline cells. This process also requires elc-1, cul-2, rbx-1 and ubc-2. | 0.778 |
mex-5 | mex-1 | W02A2.7.1 | W03C9.7a.1 | Zinc finger protein mex-5; Functions with mex-6 to affect embryonic viability, establish soma germline asymmetry in embryos and establish plk-1, pie-1, mex-1, and pos-1 asymmetry in embryos. Also affects formation of intestinal cells. Binds to mRNA in vitro, and inhibits pgl-3-mediated P-granule formation, probably by competing with pgl-3 for binding to mRNA. | Muscle EXcess. | 0.707 |
mex-5 | mex-3 | W02A2.7.1 | F53G12.5b.1 | Zinc finger protein mex-5; Functions with mex-6 to affect embryonic viability, establish soma germline asymmetry in embryos and establish plk-1, pie-1, mex-1, and pos-1 asymmetry in embryos. Also affects formation of intestinal cells. Binds to mRNA in vitro, and inhibits pgl-3-mediated P-granule formation, probably by competing with pgl-3 for binding to mRNA. | Muscle EXcess. | 0.942 |