node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
exo-1 | him-14 | F45G2.3.1 | ZK1127.11.1 | EXOnuclease. | MutS protein homolog him-14; Required during the pachytene stage of meiotic prophase for the formation of crossovers between homologous chromosomes. Not needed for pairing or synapsis. May promote crossing over by interfering with Holliday junction branch migration. Has no apparent role in DNA mismatch repair. | 0.967 |
exo-1 | him-6 | F45G2.3.1 | T04A11.6.1 | EXOnuclease. | Bloom syndrome protein homolog; Participates in DNA replication and repair (By similarity). Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (By similarity). Negatively regulates sister chromatid exchange (SCE) ; Belongs to the helicase family. RecQ subfamily. | 0.992 |
exo-1 | mlh-1 | F45G2.3.1 | T28A8.7.1 | EXOnuclease. | DNA_mis_repair domain-containing protein. | 0.998 |
exo-1 | msh-5 | F45G2.3.1 | F09E8.3a.1 | EXOnuclease. | MutS protein homolog 5; Crucial component in meiotic recombination, functioning at some point after the initiation step of recombination. Plays a role in promoting the crossover outcome of meiotic recombination events. Required for formation of normal meiotic crossover, and crossover and chiasmata generated by artificially made DNA breaks. | 0.822 |
exo-1 | mus-81 | F45G2.3.1 | C43E11.2a.1 | EXOnuclease. | ERCC4 domain-containing protein. | 0.986 |
exo-1 | pms-2 | F45G2.3.1 | H12C20.2a.1 | EXOnuclease. | PMS (Post Meiotic Segregation) family. | 0.992 |
exo-1 | rad-51 | F45G2.3.1 | Y43C5A.6a.1 | EXOnuclease. | DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. | 0.991 |
exo-1 | spo-11 | F45G2.3.1 | T05E11.4a.1 | EXOnuclease. | Meiotic recombination protein spo-11; Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. | 0.972 |
exo-1 | top-3 | F45G2.3.1 | Y56A3A.27.1 | EXOnuclease. | DNA topoisomerase 3; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)- enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Fina [...] | 0.968 |
exo-1 | zhp-3 | F45G2.3.1 | K02B12.8b.1 | EXOnuclease. | RING-type domain-containing protein. | 0.437 |
him-14 | exo-1 | ZK1127.11.1 | F45G2.3.1 | MutS protein homolog him-14; Required during the pachytene stage of meiotic prophase for the formation of crossovers between homologous chromosomes. Not needed for pairing or synapsis. May promote crossing over by interfering with Holliday junction branch migration. Has no apparent role in DNA mismatch repair. | EXOnuclease. | 0.967 |
him-14 | him-6 | ZK1127.11.1 | T04A11.6.1 | MutS protein homolog him-14; Required during the pachytene stage of meiotic prophase for the formation of crossovers between homologous chromosomes. Not needed for pairing or synapsis. May promote crossing over by interfering with Holliday junction branch migration. Has no apparent role in DNA mismatch repair. | Bloom syndrome protein homolog; Participates in DNA replication and repair (By similarity). Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (By similarity). Negatively regulates sister chromatid exchange (SCE) ; Belongs to the helicase family. RecQ subfamily. | 0.902 |
him-14 | mlh-1 | ZK1127.11.1 | T28A8.7.1 | MutS protein homolog him-14; Required during the pachytene stage of meiotic prophase for the formation of crossovers between homologous chromosomes. Not needed for pairing or synapsis. May promote crossing over by interfering with Holliday junction branch migration. Has no apparent role in DNA mismatch repair. | DNA_mis_repair domain-containing protein. | 0.991 |
him-14 | msh-5 | ZK1127.11.1 | F09E8.3a.1 | MutS protein homolog him-14; Required during the pachytene stage of meiotic prophase for the formation of crossovers between homologous chromosomes. Not needed for pairing or synapsis. May promote crossing over by interfering with Holliday junction branch migration. Has no apparent role in DNA mismatch repair. | MutS protein homolog 5; Crucial component in meiotic recombination, functioning at some point after the initiation step of recombination. Plays a role in promoting the crossover outcome of meiotic recombination events. Required for formation of normal meiotic crossover, and crossover and chiasmata generated by artificially made DNA breaks. | 0.999 |
him-14 | mus-81 | ZK1127.11.1 | C43E11.2a.1 | MutS protein homolog him-14; Required during the pachytene stage of meiotic prophase for the formation of crossovers between homologous chromosomes. Not needed for pairing or synapsis. May promote crossing over by interfering with Holliday junction branch migration. Has no apparent role in DNA mismatch repair. | ERCC4 domain-containing protein. | 0.979 |
him-14 | pms-2 | ZK1127.11.1 | H12C20.2a.1 | MutS protein homolog him-14; Required during the pachytene stage of meiotic prophase for the formation of crossovers between homologous chromosomes. Not needed for pairing or synapsis. May promote crossing over by interfering with Holliday junction branch migration. Has no apparent role in DNA mismatch repair. | PMS (Post Meiotic Segregation) family. | 0.942 |
him-14 | rad-51 | ZK1127.11.1 | Y43C5A.6a.1 | MutS protein homolog him-14; Required during the pachytene stage of meiotic prophase for the formation of crossovers between homologous chromosomes. Not needed for pairing or synapsis. May promote crossing over by interfering with Holliday junction branch migration. Has no apparent role in DNA mismatch repair. | DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. | 0.935 |
him-14 | spo-11 | ZK1127.11.1 | T05E11.4a.1 | MutS protein homolog him-14; Required during the pachytene stage of meiotic prophase for the formation of crossovers between homologous chromosomes. Not needed for pairing or synapsis. May promote crossing over by interfering with Holliday junction branch migration. Has no apparent role in DNA mismatch repair. | Meiotic recombination protein spo-11; Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. | 0.991 |
him-14 | top-3 | ZK1127.11.1 | Y56A3A.27.1 | MutS protein homolog him-14; Required during the pachytene stage of meiotic prophase for the formation of crossovers between homologous chromosomes. Not needed for pairing or synapsis. May promote crossing over by interfering with Holliday junction branch migration. Has no apparent role in DNA mismatch repair. | DNA topoisomerase 3; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)- enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Fina [...] | 0.907 |
him-14 | zhp-3 | ZK1127.11.1 | K02B12.8b.1 | MutS protein homolog him-14; Required during the pachytene stage of meiotic prophase for the formation of crossovers between homologous chromosomes. Not needed for pairing or synapsis. May promote crossing over by interfering with Holliday junction branch migration. Has no apparent role in DNA mismatch repair. | RING-type domain-containing protein. | 0.922 |