node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F32H5.1 | nep-1 | F32H5.1.1 | ZK20.6.1 | Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. | Neprilysin-1; Probable cell surface protease. Required to control the neuronal innervation of pharyngeal pumping. Belongs to the peptidase M13 family. | 0.721 |
F32H5.1 | zmp-4 | F32H5.1.1 | W09D12.1a.1 | Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. | ZnMc domain-containing protein. | 0.566 |
F32H5.1 | zmp-5 | F32H5.1.1 | H36L18.1.1 | Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. | ZnMc domain-containing protein. | 0.490 |
F44E7.4 | nep-1 | F44E7.4a.1 | ZK20.6.1 | Uncharacterized protein; Belongs to the peptidase M16 family. | Neprilysin-1; Probable cell surface protease. Required to control the neuronal innervation of pharyngeal pumping. Belongs to the peptidase M13 family. | 0.725 |
F57F5.1 | nep-1 | F57F5.1.1 | ZK20.6.1 | Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. | Neprilysin-1; Probable cell surface protease. Required to control the neuronal innervation of pharyngeal pumping. Belongs to the peptidase M13 family. | 0.721 |
F57F5.1 | zmp-4 | F57F5.1.1 | W09D12.1a.1 | Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. | ZnMc domain-containing protein. | 0.545 |
F57F5.1 | zmp-5 | F57F5.1.1 | H36L18.1.1 | Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. | ZnMc domain-containing protein. | 0.489 |
aph-2 | hop-1 | ZC434.6b.1 | C18E3.8.1 | Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch (glp-1 or lin-12). It may represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. | Presenilin hop-1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Probably works redundantly of lin-12, which provides more presenilin function. | 0.999 |
aph-2 | nep-1 | ZC434.6b.1 | ZK20.6.1 | Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch (glp-1 or lin-12). It may represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. | Neprilysin-1; Probable cell surface protease. Required to control the neuronal innervation of pharyngeal pumping. Belongs to the peptidase M13 family. | 0.723 |
aph-2 | sel-12 | ZC434.6b.1 | F35H12.3.1 | Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch (glp-1 or lin-12). It may represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. | Presenilin sel-12; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Provides the major presenilin function compared to hop-1 and spe-4. Required cell-autonomously for correct neurite connectivity of the AIY cholinergic interneurons and their correct functioning in thermotaxis. Required for mesodermal patterning of muscle function. Promotes basement membrane gap formation during tissue remodeling ; Belongs to the peptidase A22A family. | 0.999 |
aph-2 | spe-4 | ZC434.6b.1 | ZK524.1.1 | Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch (glp-1 or lin-12). It may represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. | Presenilin spe-4; Potential catalytic subunit of the gamma-secretase complex during spermatogenesis, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1) (Probable). Involved in spermatid formation during meiosis II. May be required for proper localization of macromolecules that are subject to asymmetric partitioning during spermatogenesis. | 0.999 |
cpr-8 | nep-1 | W07B8.1a.1 | ZK20.6.1 | Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. | Neprilysin-1; Probable cell surface protease. Required to control the neuronal innervation of pharyngeal pumping. Belongs to the peptidase M13 family. | 0.721 |
cpr-8 | zmp-4 | W07B8.1a.1 | W09D12.1a.1 | Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. | ZnMc domain-containing protein. | 0.511 |
cpr-8 | zmp-5 | W07B8.1a.1 | H36L18.1.1 | Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. | ZnMc domain-containing protein. | 0.489 |
hop-1 | aph-2 | C18E3.8.1 | ZC434.6b.1 | Presenilin hop-1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Probably works redundantly of lin-12, which provides more presenilin function. | Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch (glp-1 or lin-12). It may represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. | 0.999 |
hop-1 | nep-1 | C18E3.8.1 | ZK20.6.1 | Presenilin hop-1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Probably works redundantly of lin-12, which provides more presenilin function. | Neprilysin-1; Probable cell surface protease. Required to control the neuronal innervation of pharyngeal pumping. Belongs to the peptidase M13 family. | 0.776 |
hop-1 | sel-12 | C18E3.8.1 | F35H12.3.1 | Presenilin hop-1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Probably works redundantly of lin-12, which provides more presenilin function. | Presenilin sel-12; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Provides the major presenilin function compared to hop-1 and spe-4. Required cell-autonomously for correct neurite connectivity of the AIY cholinergic interneurons and their correct functioning in thermotaxis. Required for mesodermal patterning of muscle function. Promotes basement membrane gap formation during tissue remodeling ; Belongs to the peptidase A22A family. | 0.923 |
hop-1 | spe-4 | C18E3.8.1 | ZK524.1.1 | Presenilin hop-1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Probably works redundantly of lin-12, which provides more presenilin function. | Presenilin spe-4; Potential catalytic subunit of the gamma-secretase complex during spermatogenesis, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1) (Probable). Involved in spermatid formation during meiosis II. May be required for proper localization of macromolecules that are subject to asymmetric partitioning during spermatogenesis. | 0.928 |
nep-1 | F32H5.1 | ZK20.6.1 | F32H5.1.1 | Neprilysin-1; Probable cell surface protease. Required to control the neuronal innervation of pharyngeal pumping. Belongs to the peptidase M13 family. | Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. | 0.721 |
nep-1 | F44E7.4 | ZK20.6.1 | F44E7.4a.1 | Neprilysin-1; Probable cell surface protease. Required to control the neuronal innervation of pharyngeal pumping. Belongs to the peptidase M13 family. | Uncharacterized protein; Belongs to the peptidase M16 family. | 0.725 |