STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZK418.5Uncharacterized protein. (225 aa)    
Predicted Functional Partners:
nra-2
Nicalin; Involved in the recognition and selection of protein complexes to exit the endoplasmic reticulum (ER). In muscles, regulates levamisole-sensitive nicotinic acetylcholine receptor (L-AChR) subunit composition, possibly by allowing only specific L-AChR subunit combinations to exit the ER. Specifically, may promote the inclusion of alpha subunits unc-38 and unc-29 into L-AChR. Regulates L- AChR sensitivity to agonists such as nicotine and levamisole at neuro- muscular junctions. In touch neurons, may prevent ER exit of incorrectly folded mec-4-mec-10 ion channel ; Belongs to the [...]
   
 
 0.807
mrpl-2
Ribosomal_L2_C domain-containing protein.
   
   0.784
ccdc-47
CCDC (Human Coiled Coil Domain Containing) homolog.
   
 
 0.778
F22B5.10
Calcium load-activated calcium channel homolog; Calcium-selective channel required to prevent calcium stores from overfilling.
   
 
 0.762
sec-61
Plug_translocon domain-containing protein.
   
 
 0.702
mbf-1
HTH cro/C1-type domain-containing protein.
   
    0.685
K10B2.4
Protein Asterix.
   
   0.669
rpl-32
Ribosomal Protein, Large subunit.
   
   0.659
rpl-38
60S ribosomal protein L38; Belongs to the eukaryotic ribosomal protein eL38 family.
   
   0.653
rpl-4
60S ribosomal protein L4; Belongs to the universal ribosomal protein uL4 family.
   
   0.615
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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