STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hizr-1High zinc activated nuclear receptor protein; Nuclear receptor transcription factor that binds to DNA enhancer elements to promote the transcription of genes required to maintain micronutrient homeostasis. Direct binding to its ligand zinc allows for nuclear accumulation and activation, which thereby induces the transcription of genes required to promote the storage and detoxification of excess dietary zinc. This in turn, allows for internal zinc levels to be detected and regulated. (413 aa)    
Predicted Functional Partners:
cdf-2
Cation Diffusion Facilitator family.
      
 0.809
zipt-7.2
Zinc transporter zipt-7.2; Zinc transporter.
      
 0.741
zipt-2.3
Zrt (ZRT), Irt-(IRT-) like Protein Transporter.
   
  
 0.707
ttm-1
Zinc transporter ttm-1; Promotes excretion of zinc from intestinal cells into the intestinal lumen in response to increased dietary zinc. Involved in cadmium resistance, possibly by promoting its transport from cells. Involved in resistance to B.thuringiensis pore-forming toxin Cry5B downstream of the sek-1 and pmk-1 MAPK kinase pathway.
      
 0.663
H27A22.1
Peptidase_M28 domain-containing protein.
      
 0.636
zip-4
BZIP domain-containing protein.
    
 
 0.634
pax-2
Paired domain-containing protein.
  
 
   0.619
nhr-196
Nuclear Hormone Receptor family.
  
 
   0.615
zip-8
bZIP transcription factor 8.
    
 
 0.608
srw-7
G_PROTEIN_RECEP_F1_2 domain-containing protein.
    
 
 0.557
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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