STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
perm-3ER membrane protein complex subunit 4; Belongs to the EMC4 family. (174 aa)    
Predicted Functional Partners:
emc-3
ER membrane protein complex subunit 3.
   
 0.998
emc-1
EMC1_C domain-containing protein.
   
 0.997
emc-2
TPR_REGION domain-containing protein.
   
 0.997
emc-6
EMC Endoplasmic Membrane protein Complex (Yeast EMC) homolog.
   
 0.989
C35D10.1
ER membrane protein complex subunit 7 homolog.
   
 0.988
emc-5
EMC Endoplasmic Membrane protein Complex (Yeast EMC) homolog.
   
 0.984
Y43F8C.7
Uncharacterized protein.
   
 0.982
F25H2.4
MPN domain-containing protein.
   
 0.972
vps-28
Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex, a regulator of vesicular trafficking process; Belongs to the VPS28 family.
   
 
 0.918
C47G2.3
Mitochondrial import inner membrane translocase subunit tim-22; Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).
   
  
 0.916
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.