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ZK632.12 protein (Caenorhabditis elegans) - STRING interaction network
"ZK632.12" - Protein ZK632.12 in Caenorhabditis elegans
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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ZK632.12Protein ZK632.12 (ZK632.12) mRNA, complete cds (266 aa)    
Predicted Functional Partners:
C13F10.7
Protein C13F10.7 (C13F10.7) mRNA, complete cds (222 aa)
     
      0.819
R11D1.10
Protein R11D1.10, isoform a (R11D1.10) mRNA, complete cds (394 aa)
           
  0.791
lgg-2
Protein lgg-2; Ubiquitin-like modifier involved in autophagy and essential for dauer development and life-span extension. Involved in allophagy, which is an autophagic process in which paternal mitochondria and organelles are degraded during fertilization, and moreover is required for the degradation of lgg-1-positive allophagic autophagosomes in embryos. Through HOPS complex subunit vps-39, tethers lysosomes with autophagosomes to form autolysosomes. Plays a role in the distribution and clearance of germ cell specific P-granules from somatic cells; Belongs to the ATG8 family (130 aa)
     
 
  0.710
lgg-1
Protein lgg-1; Ubiquitin-like modifier involved in autophagy and essential for dauer development and life-span extension. Involved in allophagy, which is an autophagic process in which paternal mitochondria and organelles are degraded during fertilization, and moreover is required for the formation of lgg-2-positive allophagic autophagosomes in embryos. Plays a role in the distribution and clearance of germ cell specific P-granules from somatic cells. Required for normal survival when exposed to pathogenic bacteria S.typhimurium probably by promoting autophagic degradation of intracell [...] (123 aa)
     
 
  0.710
snx-14
Sorting NeXin; Protein SNX-14, isoform a (971 aa)
           
  0.707
ragc-1
RAs-related GTP binding protein C homolog; Protein RAGC-1 (ragc-1) mRNA, complete cds (338 aa)
     
 
  0.702
snx-27
Sorting NeXin; Protein SNX-27 (snx-27) mRNA, complete cds (578 aa)
           
  0.692
ost-1
SPARC; Has a high affinity for collagen. Affects nematode body morphology and mobility. Essential for C.elegans development and muscle function. The cysteine-rich region could have protease inhibitory activity or may provide the framework for a protein binding module. Probable role in skeletal morphogenesis; Belongs to the SPARC family (264 aa)
 
            0.605
vps-34
Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Together with bec-1, mediates the production of phosphatidylinositol 3-phosphate on intracellular vesicles and thereby regulates membrane trafficking. Plays a role in endosome-to-Golgi retrograde transport of mig-14. Involved in clearance of apoptotic cell corpses by phagosomes. Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3-phosphate (PI3P) on the vesicle surface which mediates recr [...] (901 aa)
     
 
  0.598
bec-1
Beclin homolog; Regulates autophagy. Together with phosphatidyl-3-phosphate kinase vps-34, acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate (PtdIns3P), thereby regulating membrane trafficking. In association with sorf-1 and sorf-2, negatively regulates phosphatidylinositol 3-phosphate in early endosomes to allow for the conversion to late endosomes. Involved in the clearance of engulfed apoptotic cell corpses. Together with ced-9, negatively regulates somatic and germline apoptosis. Plays a role in endosome-to-Golgi retrograde trans [...] (375 aa)
     
 
  0.566
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Caenorhabditis elegans, Rhabditis elegans, roundworm
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