STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nhr-255Nuclear Hormone Receptor family. (342 aa)    
Predicted Functional Partners:
ceh-6
Homeobox protein ceh-6; Vital for embryonic development and essential for the proper function of the excretory cell. Required for the transdifferentiation of the Y rectal epithelial cell to the PDA motor neuron during larval development.
  
 
   0.607
hlh-10
BHLH domain-containing protein.
  
     0.515
hlh-4
Helix-loop-helix protein 4; Acts as a transcriptional regulator. May mediate transcriptional activation by binding to the E-box motif 5'-CANNTG-3'. Required for the correct morphology, terminal identity and function of the ADL sensory neurons by controlling the expression of the ADL-specific gene repertoire, including chemoreceptor encoding genes, ion channel encoding genes, neuropeptides and the neurotransmitter eat-4. Regulates the expression of the srh-234 chemoreceptor encoding gene in the ADL neurons under feeding conditions. Plays a role in the chemorepulsive response toward asca [...]
  
     0.494
npr-12
G_PROTEIN_RECEP_F1_2 domain-containing protein.
  
     0.488
ceh-18
Homeobox protein ceh-18; Directs gonadal sheath cell differentiation and function. Also directs gonad migration and plays a role in specifying the differentiated phenotypes of epidermal cells during postembryonic development. Plays a role in oogenesis, regulating a sheath cell signal that causes oocytes to maintain diakinesis arrest during meiosis. Negatively regulates oocyte maturation, ovulation and MAPK activation in oocytes when sperm are not available for fertilization. May be recruited by akir-1 to the promoter regions of antimicrobial peptide genes to control gene expression in [...]
  
 
   0.477
npr-24
G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.
  
     0.431
ceh-49
One cut domain family member.
  
     0.420
nhr-274
NR LBD domain-containing protein.
  
     0.408
nhr-270
Nuclear Hormone Receptor family.
  
     0.400
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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