STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gld-4Poly(A) RNA polymerase gld-4; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. The enzymatic activity is enhanced by its interaction with gls-1. Required, together with gld-2, for early meiotic progression in male and female germ cells and for gld-1 protein accumulation in the hermaphrodite germline. In the germline, forms a complex with gls-1 which directly binds to gld-1 mRNA and prevents its degradation. (845 aa)    
Predicted Functional Partners:
mtr-4
mRNA transport homolog 4.
   
 
 0.920
gld-2
Poly(A) RNA polymerase gld-2; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. Acts as a regulator of mitosis/meiosis required for progression through meiotic prophase during oogenesis and spermatogenesis and for promotion of the entry into meiosis from the mitotic cell cycle. May act by regulating and activating gld-1 mRNA activity in germline.
   
  
 0.903
pap-1
Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's.
   
 
 0.894
F43G6.5
Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's.
   
 
 0.893
T15H9.6
Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's.
    
 
 0.892
nrd-1
NRD (Yeast Nuclear pre-mRNA Down-regulation) homolog.
   
 
 0.868
gld-3
Defective in germ line development protein 3; Required maternally for germline survival and embryogenesis. Forms a complex with gls-1 which promotes the oogenic cell fate by freeing the translational repressor fbf to repress sperm promoting factors. Promotes maturation of primary spermatocytes to mature sperm. Required during hermaphrodite development to promote sperm fate, which is critical for determining the normal number of sperm. Promotion of sperm fate is at the expense of oogenesis, possibly through the negative regulation of fbf. Required during male development for the continu [...]
   
  
 0.868
crn-3
HRDC domain-containing protein.
   
 
 0.863
ntl-9
NOT-Like (Yeast CCR4/NOT complex component).
   
   0.854
F07E5.5
Uncharacterized protein.
   
 
 0.793
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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